Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2016; 22(40): 8905-8909
Published online Oct 28, 2016. doi: 10.3748/wjg.v22.i40.8905
Effects of a high fat diet on intestinal microbiota and gastrointestinal diseases
Mei Zhang, Xiao-Jiao Yang
Mei Zhang, Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Xiao-Jiao Yang, McGill University, Montreal, Quebec H3A 0G4, Canada
Author contributions: The authors equally contributed to this work.
Conflict-of-interest statement: There are no potential conflicts of interest and no financial support was given.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Mei Zhang, MD, Chief Physician, Professor, Department of Gastroenterology, Xuanwu Hospital, Capital Medical University No. 45 Changchun Street, Xuanwu District, Beijing 100053, China.
Telephone: +86-10-83198438
Received: July 1, 2016
Peer-review started: July 4, 2016
First decision: August 2, 2016
Revised: August 15, 2016
Accepted: September 14, 2016
Article in press: September 14, 2016
Published online: October 28, 2016
Core Tip

Core tip: Along with the rapid development of society, lifestyles and diets have gradually changed. Due to overwhelming material abundance, high fat, high sugar and high protein diets are common. Numerous studies have determined that diet and its impact on gut microbiota are closely related to obesity and metabolic diseases. Different dietary components affect gut microbiota, thus impacting gastrointestinal disease occurrence and development. A large number of related studies are progressing rapidly. In this review, we summarize the relationship between a high fat diet, gut microbiota and gastrointestinal diseases.