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World J Gastroenterol. Sep 28, 2016; 22(36): 8161-8167
Published online Sep 28, 2016. doi: 10.3748/wjg.v22.i36.8161
Impact of hepatitis B virus infection on hepatic metabolic signaling pathway
Yi-Xian Shi, Chen-Jie Huang, Zheng-Gang Yang
Yi-Xian Shi, Chen-Jie Huang, Zheng-Gang Yang, State Key Lab of Diagnostic and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Shi YX and Yang ZG specified the topic and wrote the paper; Huang CJ performed literature search and drafted the paper.
Supported by the National Natural Science Foundation of China, No. 81270500; The State 12th 5-Year Plan S&T Projects of China, No. 2012ZX10002007; and The National Basic Research Program (973 Program) in China, No. 2013CB531400.
Conflict-of-interest statement: The authors declared that there is no conflict of interest related to this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zheng-Gang Yang, MD, PhD, State Key Lab of Diagnostic and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. yangzg@zju.edu.cn
Telephone: +86-571-87236449 Fax: +86-571-87068731
Received: May 24, 2016
Peer-review started: May 25, 2016
First decision: July 13, 2016
Revised: August 1, 2016
Accepted: August 10, 2016
Article in press: August 10, 2016
Published online: September 28, 2016
Processing time: 124 Days and 14.5 Hours
Core Tip

Core tip: Currently, hepatitis B virus (HBV) infection still poses a serious threat to public health, and causes approximately 1 million deaths annually due to HBV-related liver diseases. Thus, investigation into the complex host cellular responses to HBV infection is a crucial area of research. Multiple epidemiologic data have proved that patients with HBV infection often have metabolic disorders. Therefore, we systematically reviewed the alterations in metabolic response to HBV infection with regard to molecular mechanisms. Deciphering the detailed interplay mechanisms would contribute to our understanding of HBV-induced pathological processes and may lead to nutritional therapies as new anti-HBV treatments.