Case Control Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2016; 22(24): 5558-5567
Published online Jun 28, 2016. doi: 10.3748/wjg.v22.i24.5558
Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma
Yue-Li Nan, Yan-Ling Hu, Zhi-Ke Liu, Fang-Fang Duan, Yang Xu, Shu Li, Ting Li, Da-Fang Chen, Xiao-Yun Zeng
Yue-Li Nan, Yang Xu, Shu Li, Ting Li, Xiao-Yun Zeng, Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Yan-Ling Hu, Medical Scientific Research Centre, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Zhi-Ke Liu, Fang-Fang Duan, Da-Fang Chen, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China
Xiao-Yun Zeng, Key Laboratory of High-Incidence-Tumor Prevention and Treatment (Guangxi Medical University), Ministry of Education, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Zeng XY designed the research; Xu Y, Li S and Li T collected the materials and clinical data; Liu ZK and Duan FF performed the majority of experiments; Chen DF conceived the experimental assays; Nan YL performed the experiments, analyzed the data and wrote the manuscript; Hu YL made critical revisions of the manuscript.
Supported by National Natural Science Foundation of China, No. 81360448; Natural Science Foundation of Guangxi, No. 2014GXNSFAA118139; Fund of Key Laboratory of High-Incidence-Tumor Prevention and Treatment (Guangxi Medical University), Ministry of Education, No. GK2015-ZZ03 and No. GK2014-ZZ03; and Guangxi Outstanding Teacher Training Project for Colleges.
Institutional review board statement: The study was approved by the ethical review committee of Guangxi Medical University.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have declared that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiao-Yun Zeng, MD, PhD, Department of Epidemiology, School of Public Health, Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. zxyxjw@21cn.com
Telephone: +86-771-5358325 Fax: +86-771-5352523
Received: March 3, 2016
Peer-review started: March 7, 2016
First decision: April 14, 2016
Revised: April 29, 2016
Accepted: May 21, 2016
Article in press: May 23, 2016
Published online: June 28, 2016
Processing time: 110 Days and 1 Hours
Core Tip

Core tip: We analyzed the effects of polymorphisms of 12 cell cycle pathway genes on the risk of hepatocellular carcinoma (HCC) in a large population of 1019 HCC cases and 1138 controls. The results suggest that MCM4 rs2305952 CC and CHEK1 rs515255 TC, TT, TC/TT may be significantly associated with a decreased risk of HCC. KAT2B rs17006625 GG may increase the risk of HCC.