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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2016; 22(23): 5430-5435
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5430
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5430
Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease
Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan
Hiroyuki Okada, Seiji Kawano, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 708-0841, Japan
Yoshinori Komazawa, Division of Internal Medicine, Izumo City General Medical Center, Izumo 691-0003, Japan
Fumiya Yoshinaga, Department of Gastroenterology, Mihara Red Cross Hospital, Mihara 723-0011, Japan
Shinji Nagata, Department of Endoscopy, Hiroshima City Asa Citizens Hospital, Hiroshima 731-0293, Japan
Masafumi Inoue, Department of Gastroenterology, Okayama Red Cross Hospital, Okayama 700-0941, Japan
Hirohisa Komatsu, Department of Gastroenterology, Hiroshima General Hospital, Hiroshima 734-8551, Japan
Seiji Onogawa, Department of Gastroenterology, Onomichi General Hospital, Onomichi 722-8508, Japan
Yoshinori Kushiyama, Department of Gastroenterology, Matsue Red Cross Hospital, Matsue 690-8506, Japan
Shinichi Mukai, Department of Gastroenterology, Miyoshi Central Hospital, Miyoshi 728-0023, Japan
Hiroko Todo, Department of Gastroenterology, Hiroshima-Nishi Medical Center, Hiroshima 739-0651, Japan
Hideharu Okanobu, Department of Gastroenterology, Chugoku Rosai Hospital, Kure 737-0134, Japan
Noriaki Manabe, Department of Gastroenterology, Kawasaki Medical School Hospital, Kurashiki 701-0192, Japan
Shinji Tanaka, Department of Endoscopy, Hiroshima University Hospital, Hiroshima 734-8551, Japan
Ken Haruma, Department of General Internal Medicine 2, Kawasaki Hospital, Kawasaki Medical School, Okayama 708-0841, Japan
Yoshikazu Kinoshita, Department of Gastroenterology and Hepatology, Shimane University Hospital, Izumo 693-0021, Japan
Author contributions: Okada H, Tanaka S, Haruma K and Kinoshita Y designed this study; Takenaka R, Okada H, Kawano S, Komazawa Y, Yoshinaga F, Nagata S, Inoue M, Komatsu H, Onogawa S, Kushiyama Y, Mukai S, Todo H, Okanobu H, Manabe N and Kinoshita Y performed the research; Takenaka R and Kinoshita Y analyzed the data; Takenaka R, Okada H and Kinoshita Y wrote the paper and all co-authors approved the final version of the paper.
Supported by Taiho pharmaceutical co. Ltd.
Institutional review board statement: The study was reviewed and approved by the ethics committee of all participating institutions.
Clinical trial registration statement: This study is registered at UMIN Clinical Trial Registry. The registration identification number is UMIN000006162.
Informed consent statement: All study participants, or their legal guardian, provided informed written prior to study enrollment.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ryuta Takenaka, MD, PhD, Department of Gastroenterology, Tsuyama Chuo Hospital, 1756 Kawasaki, Tsuyama 708-0841, Japan. rtakenak@tch.or.jp
Telephone: +81-868-218111 Fax: +81-868-218201
Received: February 14, 2016
Peer-review started: February 15, 2016
First decision: March 21, 2016
Revised: April 17, 2016
Accepted: May 21, 2016
Article in press: May 23, 2016
Published online: June 21, 2016
Processing time: 119 Days and 15 Hours
Peer-review started: February 15, 2016
First decision: March 21, 2016
Revised: April 17, 2016
Accepted: May 21, 2016
Article in press: May 23, 2016
Published online: June 21, 2016
Processing time: 119 Days and 15 Hours
Core Tip
Core tip: The clinical efficacy of the second-generation H2RA lafutidine was inferior to that of lansoprazole, particularly during maintenance therapy, even in Japanese patients with mild gastroesophageal reflux disease.