Clinical Trials Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2016; 22(23): 5415-5421
Published online Jun 21, 2016. doi: 10.3748/wjg.v22.i23.5415
Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917
Elina Manzhalii, Daniel Hornuss, Wolfgang Stremmel
Elina Manzhalii, Department of Propedeutics of Internal Medicine 2, Bogomolets National Medical University, 02097 City of Kiev, Ukraine
Daniel Hornuss, Wolfgang Stremmel, Department of Gastroenterology, University Hospital of Heidelberg, 69120 Heidelberg, Germany
Author contributions: Manzhalii E is the responsible author, designed the study and performed the experiments; Hornuss D contributed by his expertise in colonic microbiota and Stremmel W wrote the manuscript.
Institutional review board statement: The study was reviewed and approved by the National Review Board of the Bogomolets National Medical University of Kiev, following the rules of the Helsinki Declaration.
Clinical trial registration statement: This registration policy applies to prospective, randomized, controlled trials only.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Authors do not have any conflict of interest to declare.
Data sharing statement: No additional data are included.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Elina Manzhalii, MD, Department of Propedeutics of Internal Medicine 2, Bogomolets National Medical University, 02097 City of Kiev, Ukraine. wolfgang.stremmel@med.uni-heidelberg.de
Telephone: + 49-6221-568700 Fax: + 49-6221-564116
Received: January 7, 2016
Peer-review started: January 8, 2016
First decision: March 7, 2016
Revised: April 8, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: June 21, 2016
Processing time: 157 Days and 18.9 Hours
Core Tip

Core tip: The occurrence of facial dermatoses with erythematous papular-pustular exanthemas is often linked to intestinal inflammation. However, the underlying mechanism remains unclear, and innovative treatment options are missing. Here we show that patients with these dermatoses carry a more aggressive microbiota associated with suppressed serum IgA levels, but increase of the proinflammatory cytokines interleukin-8 and interferon-α. Clinical manifestation, microbiota and inflammatory parameters are significantly improved by application of Escherichia coli Nissle. It indicates the usefulness of this probiotic therapy in a neglected patient population in desperate need for effective help.