Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2016; 22(22): 5254-5259
Published online Jun 14, 2016. doi: 10.3748/wjg.v22.i22.5254
Clinical significance of HOTAIR expression in colon cancer
Zhi-Fen Luo, Dan Zhao, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou
Zhi-Fen Luo, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou, Department of Oncology, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China
Dan Zhao, Department of Oncology, Zhengzhou Third People’s Hospital, Zhengzhou 450000, Henan Province, China
Author contributions: Luo ZF and Zhao D contributed equally to this work; Luo ZF and Li XQ designed the research; Cui YX, Ma N and Lu CX performed the research; Zhou Y contributed new reagents/analytic tools; Li XQ analyzed the data; Luo ZF, Zhao D and Li XQ wrote the paper.
Supported by National Natural Science Foundation of China, No. U1504820.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of Henan Provincial People’s Hospital.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yun Zhou, MD, Professor, Department of Oncology, Henan Provincial People’s Hospital, Weiwu Road No. 7, Zhengzhou 450003, Henan Province, China. luozhifen123@126.com
Telephone: +86-371-87160215
Received: March 13, 2016
Peer-review started: March 3, 2016
First decision: March 31, 2016
Revised: April 22, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: June 14, 2016
Core Tip

Core tip: This study aimed to detect the expression of HOTAIR in colon cancer and analyze its relationship with clinicopathological parameters of colon cancer. Total RNA was extracted from 80 colon cancer tissues and matched tumor-adjacent normal colon tissues and reverse transcribed. HOTAIR expression was upregulated in colon cancer, suggesting that it may play an important role in the tumorigenesis, development and metastasis of colon cancer. HOTAIR might acts as an oncogene and could be a new molecular target for the treatment of colon cancer.