Luo ZF, Zhao D, Li XQ, Cui YX, Ma N, Lu CX, Liu MY, Zhou Y. Clinical significance of HOTAIR expression in colon cancer. World J Gastroenterol 2016; 22(22): 5254-5259 [PMID: 27298568 DOI: 10.3748/wjg.v22.i22.5254]
Corresponding Author of This Article
Yun Zhou, MD, Professor, Department of Oncology, Henan Provincial People’s Hospital, Weiwu Road No. 7, Zhengzhou 450003, Henan Province, China. luozhifen123@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 14, 2016; 22(22): 5254-5259 Published online Jun 14, 2016. doi: 10.3748/wjg.v22.i22.5254
Clinical significance of HOTAIR expression in colon cancer
Zhi-Fen Luo, Dan Zhao, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou
Zhi-Fen Luo, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou, Department of Oncology, Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China
Dan Zhao, Department of Oncology, Zhengzhou Third People’s Hospital, Zhengzhou 450000, Henan Province, China
Author contributions: Luo ZF and Zhao D contributed equally to this work; Luo ZF and Li XQ designed the research; Cui YX, Ma N and Lu CX performed the research; Zhou Y contributed new reagents/analytic tools; Li XQ analyzed the data; Luo ZF, Zhao D and Li XQ wrote the paper.
Supported by National Natural Science Foundation of China, No. U1504820.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of Henan Provincial People’s Hospital.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yun Zhou, MD, Professor, Department of Oncology, Henan Provincial People’s Hospital, Weiwu Road No. 7, Zhengzhou 450003, Henan Province, China. luozhifen123@126.com
Telephone: +86-371-87160215
Received: March 13, 2016 Peer-review started: March 3, 2016 First decision: March 31, 2016 Revised: April 22, 2016 Accepted: May 4, 2016 Article in press: May 4, 2016 Published online: June 14, 2016 Processing time: 81 Days and 3.4 Hours
Abstract
AIM: To detect the expression of the long noncoding RNA HOTAIR in colon cancer and analyze its relationship with clinicopathological parameters of colon cancer.
METHODS: Total RNA was extracted from 80 colon cancer tissues and matched tumor-adjacent normal colon tissues and reverse transcribed. Quantitative polymerase chain reaction was used to detect the expression of HOTAIR. The relationship between the expression of HOTAIR and clinicopathological parameters of colon cancer was analyzed.
RESULTS: The expression of HOTAIR was significantly higher in colon cancer tissues than in matched tumor-adjacent normal colon tissues (P < 0.05). HOTAIR expression was significantly higher in cases with lymph node metastasis than in those without metastasis; in lowly differentiated and undifferentiated cases than in highly and moderately differentiated cases; and in stages III + IV cases than in stages I + II cases (P < 0.05).
CONCLUSION: HOTAIR expression is upregulated in colon cancer, suggesting that HOTAIR plays an important role in the tumorigenesis, development and metastasis of colon cancer. HOTAIR may act as an oncogene and represents a new molecular target for the treatment of colon cancer.
Core tip: This study aimed to detect the expression of HOTAIR in colon cancer and analyze its relationship with clinicopathological parameters of colon cancer. Total RNA was extracted from 80 colon cancer tissues and matched tumor-adjacent normal colon tissues and reverse transcribed. HOTAIR expression was upregulated in colon cancer, suggesting that it may play an important role in the tumorigenesis, development and metastasis of colon cancer. HOTAIR might acts as an oncogene and could be a new molecular target for the treatment of colon cancer.
