Retrospective Cohort Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2016; 22(21): 5079-5087
Published online Jun 7, 2016. doi: 10.3748/wjg.v22.i21.5079
Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse
Asuka Nakarai, Jun Kato, Sakiko Hiraoka, Shiho Takashima, Daisuke Takei, Toshihiro Inokuchi, Yuusaku Sugihara, Masahiro Takahara, Keita Harada, Hiroyuki Okada
Asuka Nakarai, Sakiko Hiraoka, Shiho Takashima, Toshihiro Inokuchi, Yuusaku Sugihara, Masahiro Takahara, Hiroyuki Okada, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-0914, Japan
Jun Kato, Second Department of Internal Medicine, Wakayama Medical University, Wakayama 641-0012, Japan
Daisuke Takei, Keita Harada, Department of Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-0914, Japan
Author contributions: All authors contributed to this paper.
Institutional review board statement: This study was reviewed and approved for publication by our Institutional Reviewer.
Informed consent statement: All study participants or their legal guardians provided informed written consent regarding personal and medical data collection prior to study enrollment.
Conflict-of-interest statement: All authors have no conflicts of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available upon request from the corresponding author at sakikoh@cc.okayama-u.ac.jp.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Sakiko Hiraoka, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. sakikoh@cc.okayama-u.ac.jp
Telephone: +39-321-3733413 Fax: +39-321-3733142
Received: March 13, 2016
Peer-review started: March 13, 2016
First decision: March 21, 2016
Revised: March 31, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: June 7, 2016
Processing time: 78 Days and 24 Hours
Core Tip

Core tip: Mucosal healing has been recognized as the treatment goal of. In this study, the relapse rate differed greatly between patients with a Mayo endoscopic subscore (MES) of 0 and an MES of 1 such that mucosal healing should be defined as an MES of 0. We previously reported that a negative fecal immunochemical test (FIT) correlates positively with mucosal healing. This paper indicated that patients with a negative FIT demonstrated a lower risk of clinical relapse than those with a positive FIT and that the risk of relapse in patients in prolonged remission and with a negative FIT was equivalent to that of patients with an MES of 0.