Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2016; 22(21): 5023-5032
Published online Jun 7, 2016. doi: 10.3748/wjg.v22.i21.5023
Interleukin-22 ameliorates acute severe pancreatitis-associated lung injury in mice
Ying-Ying Qiao, Xiao-Qin Liu, Chang-Qin Xu, Zheng Zhang, Hong-Wei Xu
Ying-Ying Qiao, Xiao-Qin Liu, Chang-Qin Xu, Zheng Zhang, Hong-Wei Xu, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China
Author contributions: Qiao YY, Liu XQ and Xu HW designed the experiments; Qiao YY, Liu XQ, Xu CQ, Zhang Z and Xu HW performed the research; Xu CQ and Xu HW contributed new reagents/analytic tools; Qiao YY, Zhang Z and Xu HW analyzed the data; Qiao YY and Liu XQ wrote the paper; Xu CQ and Xu HW revised the manuscript.
Supported by the Shandong Provincial Science and Technology Committee of China, No. 2014GGH218034.
Institutional review board statement: The study was reviewed and approved by Institutional Review Board of the Shandong Provincial Hospital Affiliated to Shandong University.
Institutional animal care and use committee statement: All animal experiments were carried out with approval by an ethics committee in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and further approved by the Institutional Care Committee (Shandong University, Jinan, China).
Conflict-of-interest statement: None of the authors have any possible conflicts of interest.
Data sharing statement: There are no additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Hong-Wei Xu, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Weiqi Road, Huai Yin District, Jinan 250021, Shandong Province, China. xu_hong_wei@sina.com
Telephone: +86-531-68776350 Fax: +86-531-87068344
Received: February 15, 2016
Peer-review started: February 17, 2016
First decision: March 21, 2016
Revised: April 11, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: June 7, 2016
Processing time: 105 Days and 8.4 Hours
Core Tip

Core tip: Interleukin-22 (IL-22) is recognized today as a key player in the antimicrobial defense, regeneration, and protection against damage. However, no reports have described the effects of IL-22 on acute severe pancreatitis (SAP)-associated lung injury. In this study, we found that IL-22 alleviated SAP-associated lung injury in mice by enhancing the expression of anti-apoptosis genes, such as Bcl-2 and Bcl-xL, through the STAT3 signaling pathway. Therefore, IL-22 and the components of STAT3 signaling pathway may be promising targets in the treatment of SAP-associated lung injury.