Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2016; 22(17): 4321-4329
Published online May 7, 2016. doi: 10.3748/wjg.v22.i17.4321
Growth hormone abolishes the negative effects of everolimus on intestinal wound healing
Markus Alexander Küper, Sebastian Trütschel, Jürgen Weinreich, Alfred Königsrainer, Stefan Beckert
Markus Alexander Küper, Sebastian Trütschel, Jürgen Weinreich, Alfred Königsrainer, Stefan Beckert, Department of General, Visceral and Transplant Surgery, University of Tübingen, 72076 Tübingen, Germany
Markus Alexander Küper, BG Trauma Center, University of Tübingen, D-72076 Tübingen, Germany
Author contributions: Küper MA, Königsrainer A and Beckert S concepted the study; Küper MA, Trütschel S and Weinreich J performed the animal studies and did the laboratory work; Küper MA, Trütschel S and Beckert S interpreted the results and did literature research; all authors wrote and revised this manuscript.
Institutional review board statement: Tierschutzgesetz in der Fassung der Bekanntmachung vom 18.05.2006.
Institutional animal care and use committee statement: All procedures were reviewed and approved by the Institutional animal care and use committee of the university of Tubingen.
Conflict-of-interest statement: All authors declare that they do not have any conflict of interest regarding this study.
Data sharing statement: The original datasets and histological specimen are available from the corresponding author at
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Markus Alexander Küper, MD, BG Trauma Center, University of Tübingen, Schnarrenbergstraße 95, D-72076 Tübingen, Germany.
Telephone: +49-7071-6063920 Fax: +49-7071-6061002
Received: January 9, 2016
Peer-review started: January 10, 2016
First decision: January 28, 2016
Revised: February 10, 2016
Accepted: March 2, 2016
Article in press: March 2, 2016
Published online: May 7, 2016
Core Tip

Core tip: Patients undergoing transplantation are set onto immunosuppressive medication afterwards. One agent is everolimus out of the group of the mTOR-inhibitors. Everolimus has been shown to inhibit healing of intestinal anastomoses by influencing the inflammatory phase of wound healing. Human growth hormone (hGH) has been shown to improve wound healing by increasing the amount of collagen in the wound. In this animal study we could demonstrate for the first time that a combined perioperative treatment with everolimus and hGH results in improved intestinal wound healing compared with everolimus alone. These results might be a step towards safer immunosuppression in transplanted patients.