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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2015; 21(7): 2236-2241
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2236
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2236
Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation
Yong-Zhen Kang, First Central clinic of Tianjin Medical University, Tianjin 300192, China
Xiao-Ye Sun, Yi-He Liu, Zhong-Yang Shen, Department of Organ Transplantation, Tianjin First Center Hospital, Tianjin Key Laboratory of Organ Transplantation, Tianjin 300192, China
Author contributions: Sun XY, Kang YZ and Shen ZY proposed the study; Sun XY, Kang YZ and Liu YH collected and analyzed the clinical data; all authors contributed to the design and interpretation of the study; Sun XY was the guarantor.
Supported by the Key Projects of Tianjin Health Bureau, No. 12KG103; and National High Technology Research and Development Program (863 Program) of China, No. 2012AA021001.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Xiao-Ye Sun, Department of Organ Transplantation, Tianjin First Center Hospital, Tianjin Key Laboratory of Organ Transplantation, 24 Fukang Road, Tianjin 300192, China. sxy_tj@163.com
Telephone: +86-22-23626612 Fax: +86-22-23626612
Received: July 28, 2014
Peer-review started: July 29, 2014
First decision: August 15, 2014
Revised: August 28, 2014
Accepted: October 15, 2014
Article in press: October 15, 2014
Published online: February 21, 2015
Peer-review started: July 29, 2014
First decision: August 15, 2014
Revised: August 28, 2014
Accepted: October 15, 2014
Article in press: October 15, 2014
Published online: February 21, 2015
Core Tip
Core tip: We report a 50-year-old man who was diagnosed with autoimmune hepatitis (AIH)-primary biliary cirrhosis (PBC) overlap syndrome 8 years after liver transplantation. His liver function tests became markedly abnormal. Standard autoimmune serological tests were positive for anti-nuclear and anti-mitochondrial antibodies, and a dramatic biochemical response was observed to a regimen consisting of prednisone and ursodeoxycholic acid added to tacrolimus immunosuppression. Liver transplant biopsy showed moderate bile duct lesions and periportal lymphocytes infiltrating along with light fibrosis, which confirmed a diagnosis of AIH-PBC overlap syndrome.