Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2015; 21(7): 2229-2235
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2229
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2229
Portal hypertension induced by congenital hepatic arterioportal fistula: Report of four clinical cases and review of the literature
Dan-Ying Zhang, Shu-Qiang Weng, Ling Dong, Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai 200032, China
Xi-Zhong Shen, Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai 200032, China
Xi-Zhong Shen, Shanghai Institute Of Liver Diseases ; Key Laboratory of Medical Molecule Virology, Ministry of Education and Health, Shanghai 200032, China
Xu-Dong Qu, Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Author contributions: Zhang DY and Qu XD performed the majority of the analyses of the clinical case; Zhang DY and Dong L acquired the data, performed the analysis and interpreted the data; Zhang DY and Weng SQ drafted the article; Shen XZ critically revised the manuscript for important intellectual content; Zhang DY and Weng SQ designed the study and wrote the manuscript; Zhang DY and Weng SQ contributed equally to this work and should be regarded as co-first authors.
Supported by National Nature Science Foundation of China No. 81000968, No. 81101540, No. 81101637, No. 81172273, No. 81272388, No. 81301820 and No. 81472673; Doctoral Fund of Ministry of Education of China No. 20120071110058, The National Clinical Key Special Subject of China.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ling Dong, Professor, Department of Gastroenterology of Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, Shanghai 200032, China. dong.ling@zs-hospital.sh.cn
Telephone: +86-21-64041990 Fax: +86-21-63148437
Received: July 15, 2014
Peer-review started: July 16, 2014
First decision: August 27, 2014
Revised: September 11, 2014
Accepted: October 20, 2014
Article in press: October 21, 2014
Published online: February 21, 2015
Processing time: 210 Days and 22.2 Hours
Peer-review started: July 16, 2014
First decision: August 27, 2014
Revised: September 11, 2014
Accepted: October 20, 2014
Article in press: October 21, 2014
Published online: February 21, 2015
Processing time: 210 Days and 22.2 Hours
Core Tip
Core tip: In Western countries, less than 10% of portal hypertension cases are caused by non-cirrhotic portal hypertension, including intrahepatic arterioportal fistula (IAPF). IAPF is a condition characterized by abnormal communication between the portal vein and the hepatic artery that most often occurs secondary to surgery, trauma, transhepatic intervention or biopsy. Currently, only 35 cases of congenital IAPF have been reported. To better understand the clinicopathological presentation of this type of portal hypertension, IAPF-induced PH confirmed by angiography was studied in four patients. Because congenital hepatic arterioportal fistulae are rare, they are often misdiagnosed.