Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2015; 21(7): 2210-2213
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2210
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2210
Human papillomavirus-related squamous cell carcinoma of the anal canal with papillary features
Marino E Leon, Domenico Coppola, Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States
Rania Shamekh, Department of Pathology and Cell Biology, University of South Florida, Tampa, FL 33612, United States
Author contributions: Leon ME designed research, performed research, analyzed data and reviewed paper; Shamekh R performed research, wrote paper and analyzed research; Coppola D designed research, analyzed data and reviewed paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Domenico Coppola, MD, Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr. Tampa, FL 33612, United States. domenico.coppola@moffitt.org
Telephone: +1-813-7453275 Fax: +1-813-7451708
Received: July 11, 2014
Peer-review started: July 12, 2014
First decision: August 6, 2014
Revised: September 5, 2014
Accepted: October 14, 2014
Article in press: October 15, 2014
Published online: February 21, 2015
Peer-review started: July 12, 2014
First decision: August 6, 2014
Revised: September 5, 2014
Accepted: October 14, 2014
Article in press: October 15, 2014
Published online: February 21, 2015
Core Tip
Core tip: Human papillomavirus (HPV)-related squamous cell carcinoma with papillary morphology has previously been reported in the oropharynx. Here, we describe the occurrence of such a tumor in the anal canal. The association with high risk HPV is demonstrated and poses the question of whether the HPV infection is responsible for this tumor phenotype.