Case Control Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2015; 21(7): 2067-2072
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2067
Increased inspiratory esophagogastric junction pressure in systemic sclerosis: An add-on to antireflux barrier
Miguel Ângelo Nobre e Souza, Patrícia Carvalho Bezerra, Rivianny Arrais Nobre, Esther Studart da Fonseca Holanda, Armênio Aguiar dos Santos
Miguel Ângelo Nobre e Souza, Patrícia Carvalho Bezerra, Rivianny Arrais Nobre, Esther Studart da Fonseca Holanda, Department of Clinical Medicine, Federal University of Ceará, Ceará CEP 60430-040, Brazil
Armênio Aguiar dos Santos, Department of Physiology and Pharmacology, Federal University of Ceará, Ceará CEP 60430-040, Brazil
Author contributions: Nobre e Souza MÂ designed the study, conducted the majority of the experiments, performed the analysis, and wrote the manuscript; Bezerra PC performed the majority of the experiments; Nobre RA performed the majority of the experiments; Holanda ESF performed the majority of the experiments; Santos AA provided financial support for this work and revised the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Miguel Ângelo Nobre e Souza, Professor, Department of Clinical Medicine, Federal University of Ceará, Costa Mendes 1608, 4º andar, Fortaleza, Ceará CEP 60430-040, Brazil. mans@ufc.br
Telephone: +55-85-33668052 Fax: +55-85-33668054
Received: April 22, 2014
Peer-review started: April 23, 2014
First decision: May 29, 2014
Revised: June 20, 2014
Accepted: July 29, 2014
Article in press: July 30, 2014
Published online: February 21, 2015
Core Tip

Core tip: Crural diaphragm adaptation in systemic sclerosis may be an add-on to the antireflux barrier. This is an indication that the antireflux barrier can be trained. Our aim was to evaluate crural diaphragm function in systemic sclerosis using high-resolution manometry and standardized inspiratory maneuvers. Systemic sclerosis patients with severe esophageal disease have increased inspiratory esophagogastric junction pressure, despite a low normal-breathing lower esophageal sphincter pressure.