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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2015; 21(48): 13457-13465
Published online Dec 28, 2015. doi: 10.3748/wjg.v21.i48.13457
Published online Dec 28, 2015. doi: 10.3748/wjg.v21.i48.13457
Fenugreek lactone attenuates palmitate-induced apoptosis and dysfunction in pancreatic β-cells
Jing Gong, Hui Dong, Shu-Jun Jiang, Ding-Kun Wang, Ke Fang, Xin Zou, Li-Jun Xu, Kai-Fu Wang, Fu-Er Lu, Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
De-Sen Yang, Department of Pharmacology, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China
Author contributions: Gong J, Dong H and Lu FE designed and wrote the article; Lu FE instructed on the whole study; Jiang SJ, Wang DK, Fang K, Yang DS, Xu LJ, Zou X and Wang KF offered proposals critically for important intellectual content; and all authors approved the final version to be published.
Supported by The National Natural Science Foundation of China, No. 81273683 and No. 81473637.
Institutional review board statement: The study was reviewed and approved by the Tongji Medical College of Huazhong University of Science and Technology Institutional Review Board.
Conflict-of-interest statement: There is no conflict of interest to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset are available. Participants gave informed consent for data sharing. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Fu-Er Lu, Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1037 Jiefang Road, Wuhan 430030, Hubei Province, China. felu@tjh.tjmu.edu.cn
Telephone: +86-27-83663237 Fax: +86-27-83663237
Received: June 14, 2015
Peer-review started: June 16, 2015
First decision: July 19, 2015
Revised: August 9, 2015
Accepted: September 28, 2015
Article in press: September 30, 2015
Published online: December 28, 2015
Peer-review started: June 16, 2015
First decision: July 19, 2015
Revised: August 9, 2015
Accepted: September 28, 2015
Article in press: September 30, 2015
Published online: December 28, 2015
Core Tip
Core tip: Fenugreek is a widely used traditional Chinese medicine that can improve hyperglycemia. The hypoglycemic active ingredients and mechanisms of fenugreek remain unclear. We studied an ingredient of fenugreek, fenugreek lactone, and our results suggest that fenugreek lactone attenuates palmitate-induced apoptosis and insulin secretion dysfunction in NIT-1 pancreatic β-cells by improving oxidative stress.