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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2015; 21(4): 1125-1139
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1125
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1125
Weichang’an and 5-fluorouracil suppresses colorectal cancer in a mouse model
Li Tao, Jin-Kun Yang, Ying Gu, Ai-Guang Zhao, Jian Zheng, Ying-Jie Zhu, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Xin Zhou, Department of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Author contributions: Tao L and Yang JK designed the research; Tao L, Gu Y and Zhao AG performed the research; Zhu YJ and Zheng J analyzed the data; and Tao L, Yang JK and GuY, Zheng J wrote the paper; Zhou X performed preparation of the Chinese medicine and quality control.
Supported by Natural Science Research Fund of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Budgetary Scientific Research Project of the Education Commission of Shanghai “The impact of Weichang’an decoction on β-catenin/MMP7 signaling pathway in nude mice with hepatic metastasis from colorectal cancer: a study on the molecular mechanism”, No. 2011JW33; Young Talent Scientific Research Project of Shanghai Municipal Commission of Health and Family Planning “Efficacy Evaluation of combined therapy with TCM and western medicine for the treatment of hepatic metastasis from unresectable colorectal cancer”, No. 20134y141.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jin-Kun Yang, Chief physician, Professor, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725, South Wanping Road, Shanghai 200032, China. yangjinkun131229@163.com
Telephone: +86-21-64385700 Fax: +86-21-64398310
Received: May 6, 2014
Peer-review started: May 11, 2014
First decision: June 10, 2014
Revised: July 17, 2014
Accepted: August 13, 2014
Article in press: August 28, 2014
Published online: January 28, 2015
Processing time: 266 Days and 1.3 Hours
Peer-review started: May 11, 2014
First decision: June 10, 2014
Revised: July 17, 2014
Accepted: August 13, 2014
Article in press: August 28, 2014
Published online: January 28, 2015
Processing time: 266 Days and 1.3 Hours
Core Tip
Core tip: In this study, the anti-colon cancer activity of Weichang’an (WCA), a Chinese herbal medicine, was assessed in an orthotopic transplantation nude mouse model. Combination of WCA with 5-fluorouracil inhibited orthotopic tumor growth and hepatic metastases. Decreased expression of β-catenin and metalloproteinase-7, which are crucial proteins modulating tumor aggression, may be important for the anti-tumor properties of WCA.