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Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2015; 21(34): 9838-9852
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9838
Recent advances in the molecular diagnostics of gastric cancer
Mitsuro Kanda, Yasuhiro Kodera
Mitsuro Kanda, Yasuhiro Kodera, Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Author contributions: Kanda M wrote the manuscript; and Kodera Y revised the manuscript for important intellectual content.
Conflict-of-interest statement: The authors have no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mitsuro Kanda, MD, PhD, Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. m-kanda@med.nagoya-u.ac.jp
Telephone: +81-52-7442249 Fax: +81-52-7442255
Received: April 5, 2015
Peer-review started: April 7, 2015
First decision: June 2, 2015
Revised: June 15, 2015
Accepted: August 25, 2015
Article in press: August 25, 2015
Published online: September 14, 2015
Processing time: 162 Days and 9.5 Hours
Core Tip

Core tip: Gastric cancer (GC), although declining in incidence in recent decades, is still the fourth most common malignancy and the third leading cause of cancer-related death worldwide. Although reliable biomarkers are necessary to improve the management of GC, conventional tumor markers have insufficient diagnostic performance. Detection of molecular markers in gastric tissue and blood samples may enhance the sensitivity and specificity of diagnostic and prognostic tests for early stage GC and provide a means to monitor recurrence and predict response to treatment. In this review, we introduce recently reported candidates for GC-related biomarkers and overview important findings.