Meta-Analysis
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2015; 21(34): 10025-10040
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.10025
CTLA-4 and MDR1 polymorphisms increase the risk for ulcerative colitis: A meta-analysis
Jia-Jun Zhao, Di Wang, Hui Yao, Da-Wei Sun, Hong-Yu Li
Jia-Jun Zhao, Di Wang, Hui Yao, Da-Wei Sun, Hong-Yu Li, Department of Gastroenterology, the General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China
Author contributions: Zhao JJ and Wang D performed the majority of experiments; Yao H provided vital reagents and analytical tools and were also involved in editing the manuscript; Sun DW co-ordinated and provided the collection of all the human material in addition to providing financial support for this work; Li HY designed the study and wrote the manuscript.
Conflict-of-interest statement: The declaration of the authors reveals that they have not received any financial payments or other benefits from any commercial entity associated with the subject of this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Hong-Yu Li, Department of Gastroenterology, the General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang 110016, Liaoning Province, China. lihongyu0913@126.com
Telephone: +86-24-28851113 Fax: +86-24-28851113
Received: January 6, 2015
Peer-review started: January 7, 2015
First decision: January 22, 2015
Revised: February 26, 2015
Accepted: May 4, 2015
Article in press: May 4, 2015
Published online: September 14, 2015
Core Tip

Core tip: To evaluate the correlations between cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and multi-drug resistance 1 (MDR1) genes polymorphisms with ulcerative colitis (UC) risk. CTLA-4 gene rs3087243 G > A and rs231775 G > A, and MDR1 gene rs1045642 C > T might confer an increases for UC risk.