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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2015; 21(28): 8678-8686
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8678
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8678
Screening for pancreatic cancer in familial high-risk individuals: A systematic review
Chao Lu, Cheng-Fu Xu, Xing-Yong Wan, Hua-Tuo Zhu, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Lu C and Xu CF contributed equally to this work; Lu C designed the research; Xu CF and Wan XY performed the research; Zhu HT contributed analytic tools. Lu C analyzed the data; Lu C and Xu CF wrote the paper; Yu CH and Li YM revised the manuscript.
Conflict-of-interest statement: Nobody has received fees for serving as a speaker. Nobody has received research funding. Xu CF, Yu CH, Li YM are employees of The First Affiliated Hospital, College of Medicine, Zhejiang University. Nobody owns stocks. Nobody owns a patent.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: You-Ming Li, Professor, Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. xiaofu@zju.edu.cn
Telephone: +86-571-87236532 Fax: +86-571-87236611
Received: December 23, 2014
Peer-review started: December 25, 2014
First decision: March 10, 2015
Revised: April 3, 2015
Accepted: June 15, 2015
Article in press: June 16, 2015
Published online: July 28, 2015
Peer-review started: December 25, 2014
First decision: March 10, 2015
Revised: April 3, 2015
Accepted: June 15, 2015
Article in press: June 16, 2015
Published online: July 28, 2015
Core Tip
Core tip: Pancreatic cancer is a fatal disease with a five-year survival rate of less than 5%. The early diagnosis of pancreatic cancer is essential. Individuals with a family history of pancreatic cancer have an increased risk of developing the disease. To date, no study has systematically and comprehensively reported on pancreatic cancer screening in familial high-risk individuals. Here, for the first time, we performed a systematic review to determine whether screening for pancreatic cancer in familial high-risk individuals can detect early stage pancreatic cancer and prolong survival or reduce the negative effects of this disease.