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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2015; 21(28): 8636-8643
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8636
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8636
Clinical characteristics of Helicobacter pylori-negative drug-negative peptic ulcer bleeding
Woo Chul Chung, Eun Jung Jeon, Dae Bum Kim, Hea Jung Sung, Yeon-Ji Kim, Eun Sun Lim, Min-ah Kim, Jung Hwan Oh, Department of Internal Medicine, St. Paul’s Hospital, College of Medicine, the Catholic University of Korea, Seoul 137-701, South Korea
Author contributions: Chung WC and Jeon EJ collected and analyzed the data, designed the research and wrote the manuscript; Kim DB, Sung HJ, Kim YJ, Lim ES, Kim M and Oh JW contributed to the paper’s conception and involved in editing the manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the Catholic University of Korea (PC14RISI0012).
Informed consent statement: Informed consent was not obtained because this study is a retrospective analysis of the clinical data collected after treatment course was completed. And the data of peptic ulcer bleeding were collected through computerized data analysis to target medical history. Therefore, this study does not affect the future treatment of patients. This study give rise to minimal risk to the patients. In this study, the patient’s clinical data collection and analysis, writing papers and papers from all over the research process, including the publication of a study were managed in secret for personal information (such as anonymized medical records). In addition, Institutional Review Board of the Catholic university of Korea, St. Paul’s hospital approved that this study has exemption from the informed consent.
Conflict-of-interest statement: The authors declare that they have nothing to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at jwchulgi@gmail.com. Informed consent was not obtained but the presented data are anonymized and risk of identification is low. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Eun Jung Jeon, MD, Department of Internal Medicine, St. Paul’s Hospital, College of Medicine, the Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, South Korea. jwchulgi@gmail.com
Telephone: +82-2-9582343 Fax: +82-2-9687250
Received: February 1, 2015
Peer-review started: February 2, 2015
First decision: March 10, 2015
Revised: March 30, 2015
Accepted: May 7, 2015
Article in press: May 7, 2015
Published online: July 28, 2015
Processing time: 178 Days and 15.5 Hours
Peer-review started: February 2, 2015
First decision: March 10, 2015
Revised: March 30, 2015
Accepted: May 7, 2015
Article in press: May 7, 2015
Published online: July 28, 2015
Processing time: 178 Days and 15.5 Hours
Core Tip
Core tip: Recently, the number of Helicobacter pylori (H. pylori)-negative and drug-negative “idiopathic” peptic ulcers has increased. This study analyzed the clinical characteristics of idiopathic peptic ulcer bleeding (PUB) and compared different etiologies, including H. pylori infection and drug use. In conclusion, definite etiologic factors of PUB including drug and H. pylori infection seemed to play an insignificant role in the severity of PUB. Idiopathic PUB has unique clinical characteristics such as re-bleeding after initial hemostasis upon admission. Therefore, these patients need to undergo close surveillance upon admission.