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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2015; 21(27): 8382-8388
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8382
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8382
Demethylation of tumor necrosis factor-α converting enzyme promoter associated with high hepatitis B e antigen level in chronic hepatitis B
Zhen-Li Wang, Shuai Gao, Xin-You Li, Feng-Kai Sun, Feng Li, Yu-Chen Fan, Kai Wang, Department of Hepatology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Yu-Chen Fan, Kai Wang, Institute of Hepatology, Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Wang ZL and Gao S performed the majority of the experiments and wrote the manuscript; Li XY and Li F collected all the human material and revised the manuscript; Sun FK and Fan YC acquired the data and performed statistical analysis; Wang K designed and supervised the study and revised the manuscript.
Supported by Key Project of Chinese Ministry of Science and Technology, No. 2012ZX10002007 and No. 2013ZX10002001; National Natural Science Foundation of China, No. 81171579, No. 81201287 and No. 81371832; Science and Technology Development Plan of Shandong Province, China, No. 2014GSF118068.
Institutional review board statement: The study was reviewed and approved by the Research and Ethics Committee at Qilu Hospital of Shandong University, China.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this work.
Data sharing statement: Technical appendix, statistical code, and data set available from the corresponding author at wangdoc876@126.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kai Wang, MD, PhD, Department of Hepatology, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Jinan 250012, Shandong Province, China. wangdoc876@126.com
Telephone: +86-531-82169596 Fax: +86-531-86927544
Received: January 26, 2015
Peer-review started: January 27, 2015
First decision: March 10, 2015
Revised: March 19, 2015
Accepted: May 4, 2015
Article in press: May 4, 2015
Published online: July 21, 2015
Peer-review started: January 27, 2015
First decision: March 10, 2015
Revised: March 19, 2015
Accepted: May 4, 2015
Article in press: May 4, 2015
Published online: July 21, 2015
Core Tip
Core tip: We retrospectively recruited 80 patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB), 80 with HBeAg-negative CHB, and 40 healthy controls. We evaluated tumor necrosis factor-α converting enzyme (TACE) promoter methylation status in peripheral blood mononuclear cells and analyzed the association between TACE methylation status and clinical features. Aberrant demethylation of the TACE promoter in HBeAg-positive CHB was associated with high HBeAg, alanine aminotransferase and aspartate aminotransferase levels. These findings imply that demethylation of the TACE promoter may potentially serve as a biomarker for HBeAg seroconversion.