Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2015; 21(27): 8293-8303
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8293
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8293
Lipid dysregulation in hepatitis C virus, and impact of statin therapy upon clinical outcomes
Tracey G Simon, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, United States
Tracey G Simon, Harvard Medical School, Boston, MA 02115, United States
Adeel A Butt, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, United States
Adeel A Butt, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
Adeel A Butt, Hamad Healthcare Quality Institute, Doha 3050, Qatar
Adeel A Butt, Hamad Medical Corporation, Doha 3050, Qatar
Author contributions: Simon TG conducted the review of existing research, and drafted the manuscript; Butt AA oversaw the literature review, and also drafted and edited the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Adeel A Butt, MD, University of Pittsburgh School of Medicine, 3601 Fifth Avenue, Suite 3A, Pittsburgh, PA 15213, United States. aabutt@pitt.edu
Telephone: +1-412-6486273 Fax: +1-412-6486399
Received: February 13, 2015
Peer-review started: February 13, 2015
First decision: March 26, 2015
Revised: April 17, 2015
Accepted: June 10, 2015
Article in press: June 10, 2015
Published online: July 21, 2015
Peer-review started: February 13, 2015
First decision: March 26, 2015
Revised: April 17, 2015
Accepted: June 10, 2015
Article in press: June 10, 2015
Published online: July 21, 2015
Core Tip
Core tip: This article reviews the complex relationship between hepatitis C virus (HCV) infection and human lipid metabolism. It discusses the aspects of the hepatitis C viral life cycle that are entwined with cholesterol homeostasis, as well as the clinical implications of HCV-mediated changes in human lipid profiles. Finally, it describes the current state of knowledge regarding the impact of statin medications on histological, virological and clinical outcomes, among patients with chronic hepatitis C.