Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2015; 21(27): 8238-8248
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8238
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8238
CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer
Michael Bordonaro, Darina L Lazarova, Department of Basic Sciences, The Commonwealth Medical College, Scranton, PA 18509, United States
Author contributions: Bordonaro M and Lazarova DL both contributed to the concept and writing of the manuscript.
Supported by National Institutes of Health (Bethesda, MD) National Cancer Institute, No. 1R15CA149589-01.
Conflict-of-interest statement: The authors have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Michael Bordonaro, PhD, Associate Professor of Molecular Biology, Department of Basic Sciences, The Commonwealth Medical College, 525 Pine Street, Scranton, PA 18509, United States. mbordonaro@tcmedc.org
Telephone: +1-570-5049646 Fax: +1-570-5049636
Received: March 30, 2015
Peer-review started: March 31, 2015
First decision: April 23, 2015
Revised: May 2, 2015
Accepted: May 27, 2015
Article in press: May 27, 2015
Published online: July 21, 2015
Processing time: 113 Days and 15.6 Hours
Peer-review started: March 31, 2015
First decision: April 23, 2015
Revised: May 2, 2015
Accepted: May 27, 2015
Article in press: May 27, 2015
Published online: July 21, 2015
Processing time: 113 Days and 15.6 Hours
Core Tip
Core tip: Deregulated Wnt/β-catenin signaling is responsible for initiating most human colorectal cancer (CRC), and hyperactivation of this pathway by histone deacetylase inhibitors such as butyrate, derived from dietary fiber, promotes CRC cell death. The transcriptional cofactors CREB-binding protein (CBP) or p300 affect Wnt signaling and the hyperactivation of this pathway by butyrate. CBP and p300 likely affect colonic tumorigenesis, stem cell fate, and butyrate resistance in CRC. Therefore, pharmacological or genetic methodologies that target CBP- and p300-mediated Wnt activity are possible preventive or therapeutic approaches against CRC.