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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2015; 21(24): 7436-7442
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7436
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7436
Inhibition of ileal bile acid transporter: An emerging therapeutic strategy for chronic idiopathic constipation
Paula Mosińska, Jakub Fichna, Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92215 Lodz, Poland
Martin Storr, Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, 81377 Munich, Germany
Author contributions: Mosińska P, Storr M, and Fichna J designed the study; Mosińska P wrote the manuscript; Storr M and Fichna J revised the manuscript.
Supported by Iuventus Plus program of the Polish Ministry of Science and Higher Education, No. 0107/IP1/2013/72 (to JF) and the grant from the Medical University of Lodz, No. 503/1-156-04/503-01.
Conflict-of-interest: The authors have no competing interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jakub Fichna, MD, PhD, Professor, Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland. jakub.fichna@umed.lodz.pl
Telephone: +48-42-272507 Fax: +48-42-2725694
Received: November 4, 2014
Peer-review started: November 4, 2014
First decision: December 11, 2014
Revised: December 19, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: June 28, 2015
Processing time: 237 Days and 10.2 Hours
Peer-review started: November 4, 2014
First decision: December 11, 2014
Revised: December 19, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: June 28, 2015
Processing time: 237 Days and 10.2 Hours
Core Tip
Core tip: Increasing the delivery of bile acids to the colon is considered one of the most promising treatment approaches for patients with constipation. This review discusses recent advances in the field of inhibitors of bile acid transporters and future perspectives in their clinical use.