Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7436
Peer-review started: November 4, 2014
First decision: December 11, 2014
Revised: December 19, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: June 28, 2015
Processing time: 237 Days and 10.2 Hours
Chronic idiopathic constipation is a common disorder of the gastrointestinal tract that encompasses a wide profile of symptoms. Current treatment options for chronic idiopathic constipation are of limited value; therefore, a novel strategy is necessary with an increased effectiveness and safety. Recently, the inhibition of the ileal bile acid transporter has become a promising target for constipation-associated diseases. Enhanced delivery of bile acids into the colon achieves an accelerated colonic transit, increased stool frequency, and relief of constipation-related symptoms. This article provides insight into the mechanism of action of ileal bile acid transporter inhibitors and discusses their potential clinical use for pharmacotherapy of constipation in chronic idiopathic constipation.
Core tip: Increasing the delivery of bile acids to the colon is considered one of the most promising treatment approaches for patients with constipation. This review discusses recent advances in the field of inhibitors of bile acid transporters and future perspectives in their clinical use.