Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2015; 21(22): 6769-6784
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.6769
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.6769
Portal vein thrombosis in cirrhosis: Controversies and latest developments
Damian J Harding, M Thamara PR Perera, Dhiraj Tripathi, Liver Unit, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
Frederick Chen, Department of Haematology, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
Simon Olliff, Department of Imaging and Interventional Radiology, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
Author contributions: All authors contributed to the manuscript.
Conflict-of-interest: Tripathi D and Olliff S have received speaker fees from Gore Medical. The other authors have not declared have any potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Dhiraj Tripathi, Liver Unit, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Edgbaston, Birmingham B15 2TH, United Kingdom. dhiraj.tripathi@uhb.nhs.uk
Telephone: +44-121-3714645 Fax: +44-121-4141833
Received: January 27, 2015
Peer-review started: January 28, 2015
First decision: February 10, 2015
Revised: March 12, 2015
Accepted: May 7, 2015
Article in press: May 7, 2015
Published online: June 14, 2015
Processing time: 141 Days and 18.1 Hours
Peer-review started: January 28, 2015
First decision: February 10, 2015
Revised: March 12, 2015
Accepted: May 7, 2015
Article in press: May 7, 2015
Published online: June 14, 2015
Processing time: 141 Days and 18.1 Hours
Core Tip
Core tip: Portal vein thrombosis is a complication of liver cirrhosis. Optimal management of portal vein thrombosis in cirrhosis has not been addressed in any consensus publication. There has been recent interest in the impact of portal vein thrombosis on the natural history of cirrhosis, and several authors have now described specific treatments for portal vein thrombosis, particularly with transjugular intrahepatic portosystemic stent-shunt and anticoagulation. We review current literature on portal vein thrombosis in cirrhosis and propose areas for future research to address unresolved clinical questions.