Editorial
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2015; 21(22): 6769-6784
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.6769
Portal vein thrombosis in cirrhosis: Controversies and latest developments
Damian J Harding, M Thamara PR Perera, Frederick Chen, Simon Olliff, Dhiraj Tripathi
Damian J Harding, M Thamara PR Perera, Dhiraj Tripathi, Liver Unit, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
Frederick Chen, Department of Haematology, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
Simon Olliff, Department of Imaging and Interventional Radiology, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
Author contributions: All authors contributed to the manuscript.
Conflict-of-interest: Tripathi D and Olliff S have received speaker fees from Gore Medical. The other authors have not declared have any potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Dhiraj Tripathi, Liver Unit, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Edgbaston, Birmingham B15 2TH, United Kingdom. dhiraj.tripathi@uhb.nhs.uk
Telephone: +44-121-3714645 Fax: +44-121-4141833
Received: January 27, 2015
Peer-review started: January 28, 2015
First decision: February 10, 2015
Revised: March 12, 2015
Accepted: May 7, 2015
Article in press: May 7, 2015
Published online: June 14, 2015
Processing time: 141 Days and 18.1 Hours
Abstract

Portal vein thrombosis (PVT) is encountered in liver cirrhosis, particularly in advanced disease. It has been a feared complication of cirrhosis, attributed to significant worsening of liver disease, poorer clinical outcomes and potential inoperability at liver transplantation; also catastrophic events such as acute intestinal ischaemia. Optimal management of PVT has not yet been addressed in any consensus publication. We review current literature on PVT in cirrhosis; its prevalence, pathophysiology, diagnosis, impact on the natural history of cirrhosis and liver transplantation, and management. Studies were identified by a search strategy using MEDLINE and Google Scholar. The incidence of PVT increases with increasing severity of liver disease: less than 1% in well-compensated cirrhosis, 7.4%-16% in advanced cirrhosis. Prevalence in patients undergoing liver transplantation is 5%-16%. PVT frequently regresses instead of uniform thrombus progression. PVT is not associated with increased risk of mortality. Optimal management has not been addressed in any consensus publication. We propose areas for future research to address unresolved clinical questions.

Keywords: Portal vein thrombosis; Liver cirrhosis; Anticoagulation; Transjugular intrahepatic portosystemic stent-shunt

Core tip: Portal vein thrombosis is a complication of liver cirrhosis. Optimal management of portal vein thrombosis in cirrhosis has not been addressed in any consensus publication. There has been recent interest in the impact of portal vein thrombosis on the natural history of cirrhosis, and several authors have now described specific treatments for portal vein thrombosis, particularly with transjugular intrahepatic portosystemic stent-shunt and anticoagulation. We review current literature on portal vein thrombosis in cirrhosis and propose areas for future research to address unresolved clinical questions.