Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2015; 21(19): 5926-5933
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5926
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5926
Risk scoring system and predictor for clinically relevant pancreatic fistula after pancreaticoduodenectomy
Ji-Ye Chen, Jian Feng, Xian-Qiang Wang, Shou-Wang Cai, Jia-Hong Dong, Yong-Liang Chen, Hospital and Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China
Author contributions: Chen YL and Dong JH designed the research. Chen JY, Cai SW, Chen YL and Dong JH performed the research; Feng J and Wang XQ analysed the data; Chen JY wrote the paper.
Ethics approval: The Chinese PLA General Hospital Institutional Review Board reviewed and approved the study.
Informed consent: All study participants, or their legal guardians, provided informed written consent before study enrolment.
Conflict-of-interest: The authors declare that there are no conflicts of interest to disclose.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yong-Liang Chen, MD, Hospital and Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. chenyongl301@163.com
Telephone: +86-10-66938331 Fax: +86-10-68241383
Received: November 2, 2014
Peer-review started: November 2, 2014
First decision: December 2, 2014
Revised: January 10, 2015
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: May 21, 2015
Peer-review started: November 2, 2014
First decision: December 2, 2014
Revised: January 10, 2015
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: May 21, 2015
Core Tip
Core tip: Clinically relevant (CR) postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD) remains a challenge, even at high-volume centres. In our study, we established a novel predictive scoring system for CR-POPF after PD based on a large number of cases in a single centre and discovered that the drain amylase level on postoperative day 3 could distinguish CR-POPF from non-clinical POPF in the early period after PD according to the different risk strata of scores. This tool could help surgeons anticipate, identify and control CR-POPF proactively, with the aim of achieving better outcomes from this daunting postoperative complication.