Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2015; 21(19): 5884-5892
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5884
Effect of microRNA-1 on hepatocellular carcinoma tumor endothelial cells
Chao Hu, Shi-Qiang Shen, Zhong-Hui Cui, Zu-Bing Chen, Wei Li
Chao Hu, Shi-Qiang Shen, Zhong-Hui Cui, Zu-Bing Chen, Wei Li, Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Hu C performed the majority of experiments, analyzed the data and wrote the paper; Shen SQ critically revised the manuscript, and approved the final version of the manuscript submitted for publication; Chen ZB designed the study; Cui ZH performed the minority of experiments; and Li W contributed analytic tools.
Ethics approval: All experiments involving animals and human subjects were designed and performed in compliance with the relevant laws regarding the humane care and use of subjects.
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Renmin Hospital of Wuhan University (IACUC protocol number: SYXK 2014-0013).
Conflict-of-interest: We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shi-Qiang Shen, MD, Department of General Surgery, Renmin Hospital of Wuhan University, 99 Zhangzhidong road, Wuchang district, Wuhan 430060, Hubei Province, China. swsw2218@hotmail.com
Telephone: +86-27-88041911 Fax: +86-27-88042292
Received: November 30, 2014
Peer-review started: December 1, 2014
First decision: December 26, 2014
Revised: January 24, 2015
Accepted: February 13, 2015
Article in press: February 13, 2015
Published online: May 21, 2015
Processing time: 171 Days and 6.7 Hours
Core Tip

Core tip: Our study demonstrated that microRNA-1 (miR-1) might be a potential tumor activator. Inhibition of the expression of miR-1 could decrease the proliferation, induce the apoptosis, and inhibit the migration and invasion of tumor endothelial cells of human hepatocellular carcinoma.