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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2015; 21(19): 5843-5855
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5843
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5843
Expression profile of microRNAs in gastrointestinal stromal tumors revealed by high throughput quantitative RT-PCR microarray
Han-Xing Tong, Yong Zhang, Jiong-Yuan Wang, Quan Jiang, Jun-Yi He, Ye-Bo Shao, Jun Zhu, Wei-Qi Lu, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Yu-Hong Zhou, Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Ying-Yong Hou, Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Yuan Huang, The Center of Endoscopy, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Bin Xie, Department of Surgery, The Central Hospital of Zaozhuang Mining Group, Zaozhuang 277000, Shandong Province, China
Wu-Mei Han, Ruo-Ying Tan, Biovue Technology Ltd, Shanghai 200032, China
Author contributions: Tong HX, Zhou YH, Hou YY and Zhang Y contributed equally to this work; Tong HX, Zhou YH, Hou YY, Lu WQ and Zhang Y designed the research plan; Tong HX, Zhou YH, Hou YY, Han WM, Xie B, Wang JY, Jiang Q, He JY and Shao YB performed the research; Tong HX, Tan RY, Zhang Y, Zhu J and Lu WQ analyzed the data; and Huang Y and Tong HX wrote the manuscript.
Supported by Grants from the Ministry of Health of the China, No. W2012RQ02; Shanghai Science and Technology Committee, No. 12nm0501402; and Shanghai Education Committee, No. 120311.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wei-Qi Lu, MD, Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. lu.weiqi@zs-hospital.sh.cn
Telephone: +86-21-64041990 Fax: +86-21-64041990
Received: July 7, 2014
Peer-review started: July 8, 2014
First decision: August 12, 2014
Revised: September 1, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: May 21, 2015
Processing time: 317 Days and 5.3 Hours
Peer-review started: July 8, 2014
First decision: August 12, 2014
Revised: September 1, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: May 21, 2015
Processing time: 317 Days and 5.3 Hours
Core Tip
Core tip: Using high throughput quantitative reverse transcription-polymerase chain reaction microarray, we obtained a panel of miRNAs including hsa-let-7c, miR-218, miR-488#, miR-4683, miR-34c-5p and miR-4773, which can distinguish malignant from benign gastrointestinal stromal tumors (GISTs). Understanding the mechanisms of GIST tumorigenesis and development, may help to further elucidate the characteristics of GIST subtypes.