Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2015; 21(18): 5513-5523
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5513
High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis
Chin Hur, Sung Eun Choi, Chung Yin Kong, Gui-Qi Wang, Hong Xu, Alexandros D Polydorides, Li-Yan Xue, Katherine E Perzan, Angela C Tramontano, Rebecca R Richards-Kortum, Sharmila Anandasabapathy
Chin Hur, Sung Eun Choi, Chung Yin Kong, Katherine E Perzan, Angela C Tramontano, Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA 02114, United States
Chin Hur, Chung Yin Kong, Harvard Medical School, Boston, MA 02114, United States
Chin Hur, Katherine E Perzan, Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, United States
Gui-Qi Wang, Department of Endoscopy, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China
Hong Xu, Department of Endoscopy, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Alexandros D Polydorides, Department of Pathology, The Mount Sinai Medical Center, Icahn School of Medicine, New York, NY 10029, United States
Li-Yan Xue, Department of Pathology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China
Rebecca R Richards-Kortum, Department of Bioengineering, Rice University, Houston, TX 77005, United States
Sharmila Anandasabapathy, Baylor Global Initiatives and the Baylor Global Innovation Center, Baylor College of Medicine, Houston, TX 77030, United States
Author contributions: Hur C, Choi SE, Richards-Kortum RR, Anandasabapathy S, Wang GQ and Xu H designed the study; Xue LY, Xu H, Wang GQ, Polydorides AD, Anandasabapathy S and Richards-Kortum RR acquired the data; Hur C, Choi SE, Kong CY, Anandasabapathy S, Richards-Kortum RR, Perzan KE and Tramontano AC wrote the manuscript.
Supported by National Institutes of Health, United States, No. R01-CA140574 and No. U01-CA152926 (to Hur C); No. R21-CA156704 and No. R01-CA181275 (to Anandasabapathy S); and No. K25-CA133141 (to Kong CY).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chin Hur, MD, MPH, GI Health Outcomes Research, Massachusetts General Hospital, 101 Merrimac Street, 10th Floor, Boston, MA 02114, United States. chur@mgh.harvard.edu
Telephone: +1-617-7244445 Fax: +1-617-7269414
Received: April 23, 2014
Peer-review started: April 24, 2014
First decision: August 7, 2014
Revised: September 3, 2014
Accepted: November 8, 2014
Article in press: November 11, 2014
Published online: May 14, 2015
Processing time: 389 Days and 18.7 Hours
Core Tip

Core tip: Half of the cases accounting for the worldwide esophageal squamous cell carcinoma (ESCC) incidence occur in China, and there may be an opportunity to improve cancer survival with improved screening and surveillance. Our aim was to use a decision-analytic Markov model to study the cost-effectiveness of incorporating high-resolution microendoscopy (HRME) into an ESCC screening program in China. Our findings show that incorporating HRME into a screening program could be cost-effective, but larger studies confirming our preliminary estimates of HRME are necessary to confirm these results.