Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2015; 21(18): 5454-5464
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5454
Downregulation of rho-associated protein kinase 1 by miR-124 in colorectal cancer
Zuo-Wu Xi, Shi-Yong Xin, Li-Qing Zhou, Hai-Xin Yuan, Qian Wang, Kai-Xuan Chen
Zuo-Wu Xi, Kai-Xuan Chen, Department of Anorectal Surgery, Henan province Hospital of Traditional Chinese Medicine (Second Affiliated Hospital of Henan University of traditional Chinese medicine), Zhengzhou 450002, Henan Province, China
Shi-Yong Xin, Hai-Xin Yuan, Qian Wang, Department of Urology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China
Li-Qing Zhou, Department of Rheumatism Immunity, First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China
Author contributions: Chen KX, Xin SY and Xi ZW designed the study and wrote the manuscript; Zhou LQ and Yuan HX performed the majority of the experiments; Wang Q provided vital reagents and analytical tools and revised he manuscript; Xin SY and Zhou LQ collected all the human material and provided financial support for this work.
Ethics approval: The study was approved by the Ethics Committee of Henan University of Traditional Chinese Medicine on Human Research (No. H20130816).
Conflict-of-interest: All authors have no conflict of interest related to the manuscript.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kai-Xuan Chen, MD, Department of Anorectal Surgery, Henan province Hospital of Traditional Chinese Medicine (Second Affiliated Hospital of Henan University of traditional Chinese medicine), Dongfeng Road No. 6, Zhengzhou 450002, Henan Province, China. doctkxchen@163.com
Telephone: +86-371-60979725 Fax: +86-371-60979726
Received: November 21, 2014
Peer-review started: November 22, 2014
First decision: December 26, 2014
Revised: January 21, 2015
Accepted: February 11, 2015
Article in press: February 11, 2015
Published online: May 14, 2015
Processing time: 177 Days and 20 Hours
Core Tip

Core tip: miR-124 inhibits neoplastic transformation, cell proliferation, and metastasis, and downregulates rho-associated protein kinase (ROCK)1 in some cancers. In this study, we investigated the roles and interactions of ROCK1 and miR-124 in human colorectal cancer (CRC). miR-124 promoted cell hyperplasia and contributed to invasion, but downregulated ROCK1 in CRC. ROCK1 and miR-124 may play important roles in CRC.