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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2015; 21(12): 3657-3662
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3657
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3657
Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B
Hong-Yu Jia, Feng Ding, Jian-Yang Chen, Jiang-Shan Lian, Yi-Min Zhang, Lin-Yan Zeng, Dai-Rong Xiang, Liang Yu, Jian-Hua Hu, Guo-Dong Yu, Huan Cai, Ying-Feng Lu, Lin Zheng, Lan-Juan Li, Yi-Da Yang, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Jia HY and Ding F contributed equally to this work; all authors contributed to this manuscript.
Supported by National Key Program for Infectious Diseases of China (to Yang YD), No. 2013ZX10002001; and 12th Five-Year Significant New Drugs Creation Plan of the Ministry of Science and Technology of China (to Yang YD), No. 2011ZX09302-003-03.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Yi-Da Yang, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital of Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. yangyida65@163.com
Telephone: +86-571-87236755 Fax: +86-571-87236755
Received: September 16, 2014
Peer-review started: September 19, 2014
First decision: October 29, 2014
Revised: November 10, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: March 28, 2015
Peer-review started: September 19, 2014
First decision: October 29, 2014
Revised: November 10, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: March 28, 2015
Core Tip
Core tip: Identifying a reliable and sensitive biomarker of early renal dysfunction would be helpful for facilitating early intervention and evaluating the effectiveness of treatments for chronic hepatitis B. Urinary β2-microglobulin and retinol-binding protein are early markers of nephrotoxicity induced by nephrotoxic substances, cardiac surgery, diabetes mellitus, or hypertension. This study shows that long-term adefovir dipivoxil therapy in patients with chronic hepatitis B results in renal impairment that correlates with abnormalities in these markers.