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World J Gastroenterol. Mar 7, 2014; 20(9): 2397-2402
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2397
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2397
RAGE gene three polymorphisms with Crohn's disease susceptibility in Chinese Han population
Zheng-Ting Wang, Rong Fan, Jie Zhou, Jie Zhong, Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
Jia-Jia Hu, Department of Nuclear Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
Author contributions: Wang ZT and Hu JJ contributed equally to this work; Zhong J contributed to the conception and design of the research; Zhong J corrected and revised the paper; Fan R and Zhou J collected samples; Wang ZT and Hu JJ performed the research and drafted the paper.
Correspondence to: Jie Zhong, Professor, Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, 600 Yushan Road, Shanghai 200025, China. jimmyzj64@medmail.com.cn
Telephone: +86-21-64370045 Fax: +86-21-64370045
Received: July 7, 2013
Revised: October 18, 2013
Accepted: December 12, 2013
Published online: March 7, 2014
Processing time: 242 Days and 3.5 Hours
Revised: October 18, 2013
Accepted: December 12, 2013
Published online: March 7, 2014
Processing time: 242 Days and 3.5 Hours
Core Tip
Core tip: The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor involved in several pathophysiological processes associated with inflammation. Therefore, we considered that RAGE gene is a candidate gene susceptible to Crohn’s disease (CD). This study is the first to investigate the association of the three most commonly studied polymorphisms in RAGE gene with CD risk in a Chinese population. The results suggest that RAGE rs1800624 and rs2070600 polymorphisms are associated with CD occurrence. The present findings support the hypothesis that a genetically impaired innate defense immunity system is a predisposing factor in the etiology of CD.