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World J Gastroenterol. Feb 14, 2014; 20(6): 1402-1423
Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1402
Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1402
Structural and functional aspects of the Helicobacter pylori secretome
Giuseppe Zanotti, Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy
Laura Cendron, Department of Biology, University of Padua, 35131 Padua, Italy
Author contributions: Zanotti G and Cendron L both wrote the paper.
Supported by the University of Padua grant “Progetto di Ateneo 2011” and by PRIN 2010-2011 “Unraveling structural and functional determinants behind Helicobacter pylori pathogenesis and persistence”
Correspondence to: Giuseppe Zanotti, Professor, Department of Biomedical Sciences, University of Padua, Viale Colombo 3, 35131 Padua, Italy. giuseppe.zanotti@unipd.it
Telephone: +39-49-8276409 Fax: +39-49-8073310
Received: September 28, 2013
Revised: December 9, 2013
Accepted: January 6, 2014
Published online: February 14, 2014
Processing time: 141 Days and 22.5 Hours
Revised: December 9, 2013
Accepted: January 6, 2014
Published online: February 14, 2014
Processing time: 141 Days and 22.5 Hours
Core Tip
Core tip: This paper summarizes what is known, from the molecular point of view, about the proteins that are secreted by the bacterium and that are generally grouped under the name “secretome”. These proteins play a very relevant role in pathogenesis, as secreted proteins or those that are present on the external surface of the bacterium are responsible of all the interactions with the host.