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World J Gastroenterol. Feb 7, 2014; 20(5): 1365-1370
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1365
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1365
Epstein-Barr virus-associated lymphoepithelioma-like early gastric carcinomas and endoscopic submucosal dissection: Case series
Ji Young Lee, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee, Jae Jun Kim, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
Kyoung-Mee Kim, Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
Author contributions: Lee JY, Kim KM and Min BH designed and performed the research; Lee JY and Min BH analyzed the data and wrote the manuscript; Lee JH, Rhee PL and Kim JJ provided critical revision of the manuscript.
Correspondence to: Byung-Hoon Min, MD, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong, Gangnam-gu, Seoul 135-710, South Korea. bhmin@skku.edu
Telephone: +82-2-34103409 Fax: +82-2-34106983
Received: September 13, 2013
Revised: November 21, 2013
Accepted: December 5, 2013
Published online: February 7, 2014
Revised: November 21, 2013
Accepted: December 5, 2013
Published online: February 7, 2014
Core Tip
Core tip: The present case studies indicate that treatment of Epstein-Barr virus (EBV)-associated early lymphoepithelioma-like gastric carcinoma (LELC) by endoscopic submucosal dissection (ESD) might have favorable long-term outcomes, despite deep submucosal invasion of tumor cells. Therefore, a conservative management strategy without additional surgery might be considered for EBV-positive early LELC with submucosal invasion treated by ESD, especially in patients with severe comorbidity and high operative risk.