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World J Gastroenterol. Feb 7, 2014; 20(5): 1348-1356
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1348
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1348
Oleanolic acid and ursolic acid inhibit proliferation in transformed rat hepatic oval cells
Yu-Ying Han, Department of Medical Genetics, Capital Medical University, Beijing 100069, China
Xiao-Wei Xue, Peng-Yan Wang, Xin-Rui Wu, Xue-Jiang Wang, Department of Pathology and Physiology, Capital Medical University, Beijing 100069, China
Zheng-Ming Shi, Department of Surgery, Beijing Jishuitan Hospital, Beijing 100035, China
Author contributions: Han YY and Xue XW designed and performed research; Shi ZM, Wang PY and Wu XR collected data and provided new reagents and analytic tools; Han YY and Wang XJ analyzed the data and performed statistical analyses; Wang XJ and Han YY wrote the paper; and all authors approved the final version to be published.
Supported by The Natural Science Foundation of Beijing Municipality, China, No. 7112010; the National Natural Science Foundation of China, No. 81272757; and the Education Commission Research Program of Beijing Municipality, China, No. KM201010025004
Correspondence to: Xue-Jiang Wang, Professor, Department of Pathology and Physiology, Capital Medical University, No. 10, You An Men Xi Tou Tiao, Beijing 100069, China. xj-w@163.com
Telephone: +86-10-83911434 Fax: +86-10-83911496
Received: September 9, 2013
Revised: November 6, 2013
Accepted: December 5, 2013
Published online: February 7, 2014
Processing time: 164 Days and 4.4 Hours
Revised: November 6, 2013
Accepted: December 5, 2013
Published online: February 7, 2014
Processing time: 164 Days and 4.4 Hours
Core Tip
Core tip: It is known that H2O2 can promote tumorigenesis. Here, we used H2O2 as a premalignant and malignant agent to induce proliferation and malignant transformation in quiescent rat liver oval cell line WB-F344. Multistage carcinogenic processes provide the basis for interrupting and reversing precancerous changes; therefore, reversing precancerous changes is critical for tumor prevention and treatment. The salient and novel findings of the study are that ursolic acid (UA) and oleanolic acid (OA) induced malignantly transformed WB-F344 cell arrest in the G1 phase and apparently inhibited the proliferation of these cells. These results better our understanding of the antitumor effects of OA and UA.