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©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Feb 7, 2014; 20(5): 1147-1154
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1147
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1147
Prevention of post-operative recurrence of Crohn’s disease
Byron Philip Vaughn, Alan Colm Moss, Division of Gastroenterology, Beth-Israel Deaconess Medical Center, Boston, MA 02115, United States
Author contributions: Vaughn BP and Moss AC contributed to the literature review, drafting and critical revision of the manuscript and formation of tables and figures; Both authors approved of the final draft.
Supported by NIH grant, No. K23DK084338 (to Moss AC); NIH training grant, No. 5T32DK007760-14 (to Vaughn BP)
Correspondence to: Byron Philip Vaughn, MD, Division of Gastroenterology, Beth-Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02115, United States. bvaughn@bidmc.harvard.edu
Telephone: +1-617-6672136 Fax: +1-617-6675826
Received: October 18, 2013
Revised: November 27, 2013
Accepted: January 2, 2014
Published online: February 7, 2014
Processing time: 125 Days and 15.7 Hours
Revised: November 27, 2013
Accepted: January 2, 2014
Published online: February 7, 2014
Processing time: 125 Days and 15.7 Hours
Core Tip
Core tip: This review summarizes and updates the current state of the field of post-operative prevention of Crohn’s disease (CD) after surgery. This review starts by discussing the natural history of postoperative recurrence followed by a summary of the most consistent and evidence based risk factors. We then discuss the evidence for medical prophylaxis of CD highlighting new data regarding biologics. Finally we discuss cost effectiveness and provide a potential novel treatment algorithm for a clinician to use practically when caring for a patient with CD after surgery.