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World J Gastroenterol. Sep 28, 2014; 20(36): 13146-13152
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13146
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13146
IL28B polymorphism genotyping as predictor of rapid virologic response during interferon plus ribavirin treatment in hepatitis C virus genotype 1 patients
Chiara Rosso, Maria Lorena Abate, Alessia Ciancio, Silvia Strona, Gian Paolo Caviglia, Antonella Olivero, Mario Rizzetto, Antonina Smedile, Department of Medical Science, University of Turin, 10123 Turin, Italy
Alessia Ciancio, Giovanni Antonio Touscoz, Mario Rizzetto, Rinaldo Pellicano, Antonina Smedile, Department of Gastroenterology and Hepatology, Molinette Hospital, 10126 Turin, Italy
Author contributions: Rosso C and Abate ML wrote the paper and contributed equally to this work; Abate ML and Smedile A designed the research; Ciancio A, Strona S, Olivero A and Touscoz GA collected the data; Rosso C and Caviglia GP performed statistical analysis; Rizzetto M, Smedile A and Pellicano R revised the paper critically for important and intellectual content.
Supported by Department of Medical Science, University of Turin
Correspondence to: Rinaldo Pellicano, MD, Department of Gastroenterology and Hepatology, Molinette Hospital, Via Cavour 31, 10126 Turin, Italy. rinaldo_pellican@hotmail.com
Telephone: +39-633-6333913 Fax: +39-633-6333976
Received: January 8, 2014
Revised: February 18, 2014
Accepted: May 12, 2014
Published online: September 28, 2014
Processing time: 266 Days and 3.1 Hours
Revised: February 18, 2014
Accepted: May 12, 2014
Published online: September 28, 2014
Processing time: 266 Days and 3.1 Hours
Core Tip
Core tip: This work provides more insights into the advantage of interleukin-28B rs12979860 and rs8099917 genotyping for therapy management in hepatitis C virus-G1 infected patients. The relevance of this approach is cost-effective at the time of decisions regarding triple therapy. We observed that in rs12979860 heterozygous patients, carriage of the rs8099917 G allele correlated with lack of viremia decrease early during treatment, when it is critical to assess for interferon sensitivity.