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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2014; 20(32): 11363-11369
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11363
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11363
''Minimizing tacrolimus'' strategy and long-term survival after liver transplantation
Jun-Jun Jia, Bin-Yi Lin, Jiang-Juan He, Lei Geng, Dhruba Kadel, Li Wang, Dong-Dong Yu, Tian Shen, Zhe Yang, Yu-Fu Ye, Lin Zhou, Shu-Sen Zheng, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Zheng SS and Zhou L conceived and designed the experiments; He JJ, Geng L, Shen T, Yang Z, Ye YF contributed reagents, materials and analytical tools; Jia JJ and Lin BY wrote the manuscript; Jia JJ, Lin BY, Kadel Dhruba, Wang L and Yu DD performed the experiments; He JJ, Geng L and Kadel D analyzed the data.
Supported by National S and T Major Program, No. 2012ZX10002004; National Natural Science Foundation of China, No. 81373160 and No. 81302074
Correspondence to: Shu-Sen Zheng, MD, PhD, FACS, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital of Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou 310003, Zhejiang Province, China. shusenzheng@zju.edu.cn
Telephone: +86-571-87236567 Fax: +86-571-87236884
Received: February 9, 2014
Revised: March 20, 2014
Accepted: April 21, 2014
Published online: August 28, 2014
Processing time: 201 Days and 1 Hours
Revised: March 20, 2014
Accepted: April 21, 2014
Published online: August 28, 2014
Processing time: 201 Days and 1 Hours
Core Tip
Core tip: Liver transplantation (LT) is a life-saving technique for patients with end-stage liver disease. Tacrolimus (TAC) is the cornerstone immunosuppressant for prevention of graft rejection in many LT centers. However, frequent TAC-related toxicities are observed and these are a major concern in LT patients. Thus, the ‘‘minimizing tacrolimus’’ strategy after LT is very important, especially in the early phase.