Topic Highlight
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2014; 20(32): 11116-11130
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11116
Genetic variants of innate immune receptors and infections after liver transplantation
Gemma Sanclemente, Asuncion Moreno, Miquel Navasa, Francisco Lozano, Carlos Cervera
Gemma Sanclemente, Asuncion Moreno, Carlos Cervera, Department of Infectious Diseases, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain
Miquel Navasa, Liver Transplant Unit, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain
Francisco Lozano, Immunology, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain
Author contributions: All authors contributed to the manuscript.
Correspondence to: Carlos Cervera, MD, PhD, Department of Infectious Diseases, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 170 C/Villarroel, 08036 Barcelona, Spain. ccervera@clinic.ub.es
Telephone: +34-93-2275430 Fax: +34-93-4514438
Received: November 6, 2013
Revised: May 14, 2014
Accepted: June 12, 2014
Published online: August 28, 2014
Processing time: 296 Days and 11 Hours
Core Tip

Core tip: After liver transplantation, immunosuppressive therapy is needed to avoid allograft rejection that is mainly mediated through adaptive immunological responses. In the setting, the existence of genetic variants of innate immunity receptors may increase the risk of post-transplant infections in comparison with patients carrying wild-type alleles. This manuscript reviews the published studies analyzing the influence of innate immunity gene variants on the development of post-transplant infections and other complications.