Electrochemiluminescence immunoassay method underestimates cortisol suppression in ulcerative colitis patients treated with oral prednisone

doi:10.3748/wjg.v20.i31.10895

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Evidence-Based Medicine

World J Gastroenterol. Aug 21, 2014; 20(31): 10895-10899
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10895

Electrochemiluminescence immunoassay method underestimates cortisol suppression in ulcerative colitis patients treated with oral prednisone

Francesco Manguso, Raffaele Bennato, Giovanni Lombardi, Assunta Viola, Elisabetta Riccio, Livio Cipolletta

Francesco Manguso, Raffaele Bennato, Giovanni Lombardi, Elisabetta Riccio, Livio Cipolletta, Division of Gastroenterology, Cardarelli Hospital, Naples 80131, Italy

Assunta Viola, Division of Haematology and Stem Cell Transplantation Unit, Cardarelli Hospital, Naples 80131, Italy

Author contributions: Manguso F and Riccio E designed research; Manguso F, Bennato R, Lombardi G, Riccio E and Viola A performed research; Viola A stored the blood samples; Manguso F analysed data; Manguso F and Bennato R wrote the paper.

Correspondence to: Francesco Manguso, MD, PhD, Division of Gastroenterology, Cardarelli Hospital, Via A. Cardarelli 9, Naples 80131, Italy. manguso@alice.it

Telephone: +39-81-7474034 Fax: +39-81-7473018

Received: February 19, 2014
Revised: April 10, 2014
Accepted: May 25, 2014
Published online: August 21, 2014
Processing time: 182 Days and 11.1 Hours

Core Tip

Core tip: The determination of morning cortisol levels is used in clinical practice and as specific safety endpoint in various clinical trials. This study was designed to compare the efficacy of electrochemiluminescent assays (ECLIA) method and liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measurement of cortisolemia in active ulcerative colitis (UC) patients treated with oral prednisone (PD). Blood cortisol levels detected with ECLIA method are higher than the ones measured by LC-MS/MS, indicating a possible overestimation of them in UC patients treated with PD. Therefore, the cortisol suppression in patients under treatment with oral PD should not be measured using ECLIA method.