Electrochemiluminescence immunoassay method underestimates cortisol suppression in ulcerative colitis patients treated with oral prednisone

doi:10.3748/wjg.v20.i31.10895

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 20, Issue 31

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5933)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-1) series.

Item

Count

PDF

492

WORD

283

HTML

3125

Figures (1-3)

180

Tables (1-1)

122

Sum=4202

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

949

Download

782

Sum=1731

Aug 21, 2014 (publication date) through May 7, 2024

Times Cited of This Article

Times Cited (7)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Evidence-Based Medicine

World J Gastroenterol. Aug 21, 2014; 20(31): 10895-10899
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10895

Electrochemiluminescence immunoassay method underestimates cortisol suppression in ulcerative colitis patients treated with oral prednisone

Francesco Manguso, Raffaele Bennato, Giovanni Lombardi, Assunta Viola, Elisabetta Riccio, Livio Cipolletta

Francesco Manguso, Raffaele Bennato, Giovanni Lombardi, Elisabetta Riccio, Livio Cipolletta, Division of Gastroenterology, Cardarelli Hospital, Naples 80131, Italy

Assunta Viola, Division of Haematology and Stem Cell Transplantation Unit, Cardarelli Hospital, Naples 80131, Italy

Author contributions: Manguso F and Riccio E designed research; Manguso F, Bennato R, Lombardi G, Riccio E and Viola A performed research; Viola A stored the blood samples; Manguso F analysed data; Manguso F and Bennato R wrote the paper.

Correspondence to: Francesco Manguso, MD, PhD, Division of Gastroenterology, Cardarelli Hospital, Via A. Cardarelli 9, Naples 80131, Italy. manguso@alice.it

Telephone: +39-81-7474034 Fax: +39-81-7473018

Received: February 19, 2014
Revised: April 10, 2014
Accepted: May 25, 2014
Published online: August 21, 2014

Core Tip

Core tip: The determination of morning cortisol levels is used in clinical practice and as specific safety endpoint in various clinical trials. This study was designed to compare the efficacy of electrochemiluminescent assays (ECLIA) method and liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measurement of cortisolemia in active ulcerative colitis (UC) patients treated with oral prednisone (PD). Blood cortisol levels detected with ECLIA method are higher than the ones measured by LC-MS/MS, indicating a possible overestimation of them in UC patients treated with PD. Therefore, the cortisol suppression in patients under treatment with oral PD should not be measured using ECLIA method.