Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer

doi:10.3748/wjg.v20.i31.10813

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Aug 21, 2014 (publication date) through Jul 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2014; 20(31): 10813-10824
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10813

Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer

Daisuke Kyuno, Hiroshi Yamaguchi, Tatsuya Ito, Tsuyoshi Kono, Yasutoshi Kimura, Masafumi Imamura, Takumi Konno, Koichi Hirata, Norimasa Sawada, Takashi Kojima

Daisuke Kyuno, Hiroshi Yamaguchi, Tatsuya Ito, Tsuyoshi Kono, Yasutoshi Kimura, Masafumi Imamura, Koichi Hirata, Department of Surgery, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan

Tsuyoshi Kono, Takumi Konno, Takashi Kojima, Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan

Norimasa Sawada, Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan

Author contributions: Kyuno D and Kojima T contributed equally to this work; Yamaguchi H, Ito T, Kono T, Kimura Y, Imamura M, Konno T, Hirata K and Sawada N designed the research; Kyuno D and Kojima T wrote the paper.

Supported by Ministry of Education, Culture, Sports Science, and Technology, and the Ministry of Health, Labour and Welfare of Japan

Correspondence to: Takashi Kojima, PhD, Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, South 1, West 17, Sapporo 060-8556, Japan. ktakashi@sapmed.ac.jp

Telephone: +81-11-6112111 Fax: +81-11-6112299

Received: October 25, 2013
Revised: January 11, 2014
Accepted: April 30, 2014
Published online: August 21, 2014
Processing time: 300 Days and 0.9 Hours

Core Tip

Core tip: There is an urgent need to develop novel diagnostic and therapeutic strategies to reduce the mortality of pancreatic cancer patients. In pancreatic cancer, some tight junction proteins, including claudins, are abnormally regulated and thus are promising molecular targets for Clostridium perfringens enterotoxin and monoclonal antibodies. Protein kinase C is closely related to epithelial to mesenchymal transition (EMT) of this cancer and regulates tight junctions of normal human pancreatic duct epithelial (HPDE) cells and pancreatic cancer cells. This review focuses on the regulation of tight junctions via protein kinase C during EMT in human pancreatic cancer compared to normal HPDE cells.