Topic Highlight
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2014; 20(31): 10758-10768
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10758
Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer
Barbara Bournet, Marion Gayral, Jérôme Torrisani, Janick Selves, Pierre Cordelier, Louis Buscail
Barbara Bournet, Louis Buscail, Department of Gastroenterology, CHU Toulouse Rangueil, University of Toulouse, 31059 Toulouse, France
Barbara Bournet, Marion Gayral, Jérôme Torrisani, Janick Selves, Pierre Cordelier, Louis Buscail, INSERM UMR 1037, CHU Toulouse Rangueil, University of Toulouse, 31059 Toulouse, France
Janick Selves, Department of Pathology, CHU Toulouse Purpan, University of Toulouse, 31059 Toulouse, France
Author contributions: Bournet B, Selves J, Cordelier P and Buscail L collected and analysed the data, designed and wrote the manuscript; Gayral M and Torrisani J wrote and revised the manuscript.
Correspondence to: Louis Buscail, MD, PhD, Department of Gastroenterology, CHU Toulouse Rangueil, University of Toulouse, 1 avenue Jean Poulhès, TSA 50032, 31059 Toulouse, France. buscail.l@chu-toulouse.fr
Telephone: +33-5-61323055 Fax: +33-5-61322229
Received: October 28, 2013
Revised: January 12, 2014
Accepted: April 15, 2014
Published online: August 21, 2014
Processing time: 296 Days and 10.2 Hours
Core Tip

Core tip: This review depicts the widespread potential for the molecular analysis of samples obtained by ultrasound-guided fine needle aspiration in assessing diagnosis or prognosis of pancreatic adenocarcinoma, as well as translational studies on new markers and epigenetic alterations. Among these markers, Kras oncogene assay appears now the most robust for improvement of positive and differential diagnosis of pancreatic cancer. Clinical implication of miRNA, Mucins and markers of invasion is still debated. Future molecular developments may open windows towards personalized treatments after molecular characterization of a single patient.