Molecular confocal laser endomicroscopy: A novel technique for in vivo cellular characterization of gastrointestinal lesions

doi:10.3748/wjg.v20.i24.7794

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Jun 28, 2014 (publication date) through May 8, 2024

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 28, 2014; 20(24): 7794-7800
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7794

Molecular confocal laser endomicroscopy: A novel technique for in vivo cellular characterization of gastrointestinal lesions

John Gásdal Karstensen, Pia Helene Klausen, Adrian Saftoiu, Peter Vilmann

John Gásdal Karstensen, Pia Helene Klausen, Adrian Saftoiu, Peter Vilmann, Gastro Unit, Division of Endoscopy, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark

Adrian Saftoiu, Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy of Craiova, 200349 Dolj, Romania

Author contributions: Karstensen JG, Klausen PH, Saftoiu A and Vilmann P contributed to the manuscript.

Supported by ERC-like nr. 7/2012 “Real-time Evaluation of Treatment Effects in Advanced Colorectal Carcinoma (REACT)”, project ID PNII-CT-ERC-2012-1, financed by the Executive Agency for Higher Education, Research, Development and Innovation Funding (CNCS-UEFISCDI), Romanian National Authority for Scientific Research, Ministry of National Education, ROMANIA. Establishment of confocal laser endomicroscopy in Copenhagen was possible due to the generous contributions of A.P. Møller and Chastine McKinney Møllers Foundation, Foundation Jochum, The Toyota Foundation and the Foundation of Aase and Ejnar Danielsen. The Foundation of Arvid Nilsson and The Lundbeck Foundation supported the activity of JGK and AS, respectively

Correspondence to: Adrian Saftoiu, MD, Phd, MSc, FASGE, Professor of Diagnostic and Therapeutic Techniques in Gastroenterology, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy Craiova, str. Petru Rares 4, Craiova, 200349 Dolj, Romania. adrian.saftoiu@umfcv.ro

Telephone: +40-744-823355 Fax: +40-251-310287

Received: October 28, 2013
Revised: January 14, 2014
Accepted: March 19, 2014
Published online: June 28, 2014

Core Tip

Core tip: Confocal laser endomicroscopy (CLE) enables cellular visualization during on-going endoscopy. Lately, the method has been further refined by using fluorescent labelled molecular probes for estimation of receptors in carcinomas, illumination of subtle lesions and assessment of the affinity of drugs to specific lesions. This article presents the method of molecular CLE and gives a review of the current applications and drawbacks.