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World J Gastroenterol. Jun 28, 2014; 20(24): 7525-7533
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7525
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7525
Hepatocellular carcinoma: Surgical perspectives beyond the barcelona clinic liver cancer recommendations
Alfredo Guglielmi, Andrea Ruzzenente, Simone Conci, Alessandro Valdegamberi, Marco Vitali, Francesca Bertuzzo, Michela De Angelis, Guido Mantovani, Calogero Iacono, Department of Surgery, Division of General Surgery A, Unit of Hepato-Pancreatico-Biliary surgery, University of Verona Medical School, 37134 Verona, Italy
Author contributions: Guglielmi A, Ruzzenente A and Iacono C designed the research and supervised the paper; Ruzzenente A, Conci S and Valdegamberi A wrote the paper; Conci S, Valdegamberi A, Vitali M, Bertuzzo F, De Angelis M and Mantovani G performed the literature research; Iacono C and Guglielmi A provided critical expertise and reviewed the paper.
Correspondence to: Calogero Iacono, Professor, Department of Surgery, Division of General Surgery A, Unit of Hepato-Pancreatico-Biliary surgery, University of Verona Medical School, University Hospital “GB Rossi”, P.le L.A. Scuro, 37134 Verona, Italy. calogero.iacono@univr.it
Telephone: +39-45-8124412 Fax: +39-45-8027426
Received: November 20, 2013
Revised: January 17, 2014
Accepted: March 19, 2014
Published online: June 28, 2014
Revised: January 17, 2014
Accepted: March 19, 2014
Published online: June 28, 2014
Core Tip
Core tip: The present review reports the results of surgery beyond the barcelona clinic liver cancer recommendations. Recent studies have reported that surgical resection can result in good short- and long-term survival in patients with early hepatocellular carcinoma (HCC) with portal hypertension and in patients with intermediate-advanced HCC. A careful preoperative evaluation, including liver function and remnant volume assessment, is mandatory before liver resection in HCC patients. An understanding of the biological behaviour of these tumours through molecular biology studies may be useful in choosing the optimal treatment strategy.