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World J Gastroenterol. Jan 14, 2014; 20(2): 498-508
Published online Jan 14, 2014. doi: 10.3748/wjg.v20.i2.498
Published online Jan 14, 2014. doi: 10.3748/wjg.v20.i2.498
Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency
Ying-Yin Ni, Yan Chen, Fang Wang, Xiao-Lin Wu, Su-Ying Dang, Ming-Min Gu, Zhu-Gang Wang, Department of Medical Genetics, E-Institutes of Shanghai Universities, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Shun-Yuan Lu, Hong-Xin Zhang, Zhu-Gang Wang, Research Centre for Experimental Medicine, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Bi-Ying Sun, Guo-Hua Zhang, Wei-Fang Rong, Department of Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Yin Kuang, Jian Fei, Zhu-Gang Wang, Shanghai Research Centre for Model Organisms, Shanghai 201210, China
Author contributions: Rong WF and Wang ZG designed the research; Ni YY, Chen Y, Lu SY, Sun BY and Kuang Y performed the research; Wang F, Wu XL, Dang SY, Zhang GH and Zhang HX contributed new reagents/materials/ analytic tools; Fei J, Gu MM, Rong WF and Wang ZG analyzed the data; Ni YY, Rong WF and Wang ZG wrote the paper.
Supported by Shanghai Municipal Health Bureau Foundation, No. 2010037; and the National Natural Science Foundation of China, Nos. 30900156, 81071444 and 31000986
Correspondence to: Wei-Fang Rong, Professor, Director, Department of Physiology, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. weifangrong@shsmu.edu.cn
Telephone: +86-21-63846590 Fax: +86-21-64370045
Received: June 14, 2013
Revised: September 15, 2013
Accepted: October 17, 2013
Published online: January 14, 2014
Processing time: 219 Days and 4.4 Hours
Revised: September 15, 2013
Accepted: October 17, 2013
Published online: January 14, 2014
Processing time: 219 Days and 4.4 Hours
Core Tip
Core tip: The Adhesion family is the second largest subfamily of the G-protein-coupled receptors (GPCR). The physiological function of the orphan Adhesion-GPCR Gpr128 is unknown. In the present study, we generated Gpr128 knockout mice and confirmed the selective expression of Gpr128 in the intestinal tissues. Phenotypic analysis revealed that targeted deletion of Gpr128 in the mouse resulted in reduced body weight gain and increased frequency of peristaltic contraction and slow wave potential in the small intestine. The physiological roles of Gpr128 in the gastrointestinal tract and its potential as a therapeutic target for obesity and nutritional disorders warrant further investigation.