Däbritz J, Musci J, Foell D. Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome. World J Gastroenterol 2014; 20(2): 363-375 [PMID: 24574706 DOI: 10.3748/wjg.v20.i2.363]
Corresponding Author of This Article
Dirk Foell, MD, Professor, Director, Department of Paediatric Rheumatology and Immunology, University Children’s Hospital Münster, Röntgenstr. 21, 48149 Münster, Germany. dfoell@uni-muenster.de
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
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World J Gastroenterol. Jan 14, 2014; 20(2): 363-375 Published online Jan 14, 2014. doi: 10.3748/wjg.v20.i2.363
Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome
Jan Däbritz, Jason Musci, Dirk Foell
Jan Däbritz, Gastrointestinal Research in Inflammation and Pathology, Murdoch Children’s Research Institute, The Royal Children’s Hospital Melbourne, Parkville 3052, VIC, Australia
Jan Däbritz, Jason Musci, Department of Paediatrics, Melbourne Medical School, University of Melbourne, Parkville 3052, VIC, Australia
Jan Däbritz, Dirk Foell, Department of Paediatric Rheumatology and Immunology, University Children’s Hospital Münster, 48149 Münster, Germany
Author contributions: Däbritz J and Musci J contributed equally to this work; Däbritz J, Musci J and Foell D analysed and interpreted data; Däbritz J created tables and figures; Däbritz J and Musci J wrote the paper; Foell D critically reviewed and submitted the manuscript; Däbritz J, Musci J and Foell D read and approved the final version of the manuscript.
Supported by A research fellowship awarded to Däbritz J by the German Research Foundation, No. DFG DA1161/5-1
Correspondence to: Dirk Foell, MD, Professor, Director, Department of Paediatric Rheumatology and Immunology, University Children’s Hospital Münster, Röntgenstr. 21, 48149 Münster, Germany. dfoell@uni-muenster.de
Telephone: +49-251-8358178 Fax: +49-251-8358104
Received: September 9, 2013 Revised: November 12, 2013 Accepted: November 28, 2013 Published online: January 14, 2014 Processing time: 131 Days and 15.8 Hours
Core Tip
Core tip: Faecal markers of intestinal inflammation represent a practicable, non-invasive, inexpensive and objective diagnostic tool to differentiate organic [inflammatory bowel disease (IBD)] and functional [irritable bowel syndrome (IBS)] gastrointestinal diseases. Faecal markers have the potential to be incorporated into standard clinical practice for the routine assessment of IBS and IBD. Neutrophil-derived faecal biomarkers show a high diagnostic accuracy in the differentiation of IBD vs IBS. They can provide reassurance to the physicians that the clinical diagnosis of IBS is correct. Future progress in our knowledge about the biology of these proteins and the underlying pathogenesis of IBS will help translate IBD/IBS research into patient care.
