Point shear wave elastography method for assessing liver stiffness

doi:10.3748/wjg.v20.i16.4787

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Apr 28, 2014 (publication date) through Apr 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2014; 20(16): 4787-4796
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4787

Point shear wave elastography method for assessing liver stiffness

Giovanna Ferraioli, Carmine Tinelli, Raffaella Lissandrin, Mabel Zicchetti, Barbara Dal Bello, Gaetano Filice, Carlo Filice

Giovanna Ferraioli, Raffaella Lissandrin, Mabel Zicchetti, Gaetano Filice, Carlo Filice, Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, Medical School University of Pavia, 27100 Pavia, Italy

Carmine Tinelli, Clinical Epidemiology and Biometric Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy

Barbara Dal Bello, Department of Pathology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy

Author contributions: Ferraioli G and Tinelli C contributed equally to this work; Ferraioli G, Tinelli C and Filice C designed the research; Ferraioli G, Lissandrin R, Zicchetti M and Dal Bello B performed the research; Tinelli C analyzed the data; Ferraioli G, Zicchetti M and Lissandrin R wrote the manuscript; Tinelli C, Dal Bello B, Filice G and Filice C reviewed the manuscript; and Ferraioli G, Tinelli C, Dal Bello B, Zicchetti M, Lissandrin R, Filice G and Filice C approved the final version of the manuscript; all the authors of the Liver Fibrosis Study Group performed the research, reviewed the manuscript and approved the final version.

Supported by The FibroScan device was made available for this study by Echosens (Paris, France), and the iU22 ultrasound equipment was provided by Philips Medical Systems (Bothell, WA, United States)

Correspondence to: Giovanna Ferraioli, MD, Researcher, Ultrasound Unit, Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, Medical School University of Pavia, Via Taramelli 5, 27100 Pavia, Italy. giovanna.ferraioli@unipv.it

Telephone: +39-382-502887 Fax: +39-382-501505

Received: January 13, 2014
Revised: February 9, 2014
Accepted: March 8, 2014
Published online: April 28, 2014

Core Tip

Core tip: The results of this study show that point shear-wave elastography (PSWE) is a highly reproducible method for assessing liver stiffness that is characterized by high levels of intraobserver and interobserver agreement, both overall and for single measurements. The PSWE performance compares with that of transient elastography (TE), the most widely accepted method for the noninvasive assessment of liver fibrosis. Compared with TE, routine ultrasound with elastography is advantageous because it allows the evaluation of other parameters that are complementary to stiffness, is highly accurate for the diagnosis of cirrhosis and can be used to screen for focal liver lesions.