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World J Gastroenterol. Apr 28, 2014; 20(16): 4771-4777
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4771
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4771
Intravenous infusion of mesenteric lymph from severe intraperitoneal infection rats causes lung injury in healthy rats
Yan-Min Zhang, Tianjin Medical University, Intensive Care Unit, Tianjin Nankai Hospital, Tianjin 300100, China
Shu-Kun Zhang, Tianjin Nankai Hospital, Tianjin 300100, China
Nai-Qiang Cui, Department of Surgery, Tianjin Nankai Hospital, Tianjin 300100, China
Author contributions: Zhang YM performed the majority of experiments and wrote the manuscript; Zhang SK provided vital reagents and analytical tools; Cui NQ designed the study and revised the manuscript.
Supported by National Natural Science Foundation of China, No.2009CB522703
Correspondence to: Nai-Qiang Cui, Chief, Department of Surgery, Tianjin Nankai Hospital, 6 Changjiang Road, Nankai District, Tianjin 300100, China. summer9531@163.com
Telephone: +86-22-23746095 Fax: +86-22-27435365
Received: November 1, 2013
Revised: January 24, 2014
Accepted: March 5, 2014
Published online: April 28, 2014
Processing time: 178 Days and 19.7 Hours
Revised: January 24, 2014
Accepted: March 5, 2014
Published online: April 28, 2014
Processing time: 178 Days and 19.7 Hours
Core Tip
Core tip: We previously speculated that the lymphatic pathway plays a leading role in the early lung injury caused by severe intraperitoneal infection (SII), and that the mesenteric lymph may be the original source of organ damage. Here, we infused mesenteric lymph from rats with SII into healthy rats to investigate the effect on lung tissues. We confirmed that the damage to the remote organ was caused via the mesenteric lymphatic pathway.